249897-21-0Relevant articles and documents
The regioselective bromine-lithium exchange reaction of alkoxymethyldibromobenzene: A new strategy for the synthesis of tofogliflozin as a SGLT2 inhibitor for the treatment of diabetes
Murakata, Masatoshi,Ikeda, Takuma,Kimura, Nobuaki,Kawase, Akira,Nagase, Masahiro,Kimura, Masahiro,Maeda, Kenji,Honma, Akie,Shimizu, Hitoshi
, p. 655 - 660 (2017)
The regioselective bromine-lithium exchange reaction of 2,4-dibromo-1-(1-methoxy-1-methylethoxymethyl)benzene (2), which resulted in optimized selectivity of 220:1, is described. Applying this method to the synthesis of tofogliflozin (1) as a SGLT2 inhibi