25006-88-6

Basic information

• Product Name: 2-bromo-1,3-bis(bromomethyl)benzene
• Synonyms: 2-bromo-1,3-bis(bromomethyl)benzene;alpha,alpha',2-Tribromo-m-xylene
• CAS NO: 25006-88-6
• Molecular Formula: C₈H₇Br₃
• Molecular Weight: 342.85318
• Mol File: 25006-88-6.mol
• Article Data: 20

Chemical Properties

• Melting Point: 101-103 °C
• Boiling Point: 333.4±32.0 °C(Predicted)
• Appearance: /
• Density: 2.082±0.06 g/cm3(Predicted)
• CAS DataBase Reference: 2-bromo-1,3-bis(bromomethyl)benzene(CAS DataBase Reference)
• NIST Chemistry Reference: 2-bromo-1,3-bis(bromomethyl)benzene(25006-88-6)
• EPA Substance Registry System: 2-bromo-1,3-bis(bromomethyl)benzene(25006-88-6)

Safety Data

• RIDADR: 3261
• Hazardous Substances Data: 25006-88-6(Hazardous Substances Data)

Usage

General Description

2-bromo-1,3-bis(bromomethyl)benzene, also known as dibromomethylbenzene, is a chemical compound with the molecular formula C8H6Br4. It is a colorless to pale yellow liquid that is insoluble in water but soluble in organic solvents. 2-bromo-1,3-bis(bromomethyl)benzene is primarily used as an intermediate in the production of pharmaceuticals, agrochemicals, and other organic compounds. It is also utilized in the synthesis of polymers and as a reagent in organic chemistry reactions. Due to its bromine substituents, it is considered to be a halogenated organic compound and must be handled and disposed of with caution to prevent environmental contamination.

Upstream product

• 576-22-7 2-Bromo-m-xylene 
• 66790-58-7 2-bromo-1-(bromomethyl)-3-methylbenzene 
• 87-62-7 2,6-dimethylaniline 

Downstream Products

• 130131-74-7 2,6-bis<(pyrazol-1-yl)methyl>bromobenzene 
• 131508-08-2 2,6-(C₆H₃Br(CH₂N(i-Pr)Me)2-2,6) 
• 131508-09-3 2,6-((t-Bu)MeNCH₂)2C₆H₃Br 
• 133969-57-0 1,3-bis<(2-methoxyethoxy)methyl>-2-bromobenzene 
• 77776-06-8 9-Brom-18-phenyl-2,11-dithia<3.3>metacyclophan 
• 138450-23-4 1,3-Bis-[2-benzenesulfonyl-2-(2-bromo-phenyl)-ethyl]-2-bromo-benzene 
• 131298-26-5 8-Brom-17,17,18,18-tetradehydro-1,10-bis(p-tolylsulfonyl)-1,10-diaza<2>(1,3)benzeno<2>(1,2)benzeno<2>(1,2)benzenophan 
• 138450-25-6 C₃₆H₃₁Br₃O₄S₂ 
• 138450-27-8 C₄₂H₃₁Br₃O₄S₂ 
• 158059-30-4 2,6-Bis<((S)-2-methyl-1-pyrrolidinyl)methyl>bromobenzene 
• 157943-62-9 2,6-Bis<<(S)-2-(isopropoxycarbonyl)-1-pyrrolidinyl>methyl>bromobenzene 
• 131508-07-1 2,6-(Ph₂NCH₂)2C₆H₃Br 
• 66479-06-9 1-bromo-2,6-bis-((dimethylamino)methyl)benzene 
• 131508-12-8 [2-Bromo-3-(tert-butylamino-methyl)-benzyl]-tert-butyl-amine 

Relevant articles and documents

A Tethered Tolane: Twisting the Excited State

The synthesis of a doubly bridged tolane is reported. The target is obtained in a five-step synthesis, starting from commercially available 2-amino-meta-xylene by a combination of a Sandmeyer reaction, radical bromination, and Stille-type coupling, followed by double ring closing. The doubly tethered tolane is crystalline; the two phenyl rings are highly twisted with respect to each other both in solution and in the solid state. Optical spectroscopy and quantum chemical calculations show that the doubly bridged tolane is twisted not only in the ground state, but also in the excited state, leading to emission from the twisted state in solution and in the solid state. Strong phosphorescence is observed at cryogenic temperatures.

A Convenient New Synthesis of Benzo[a]pyrene

A convenient new synthesis of the ubiquitous environmental carcinogen benzo[a]pyrene (BaP) is described. In the key step, the method entails Suzuki coupling of naphthalene 2-boronic acid with 2-bromobenzene-1,3-dialdehyde and requires only three steps. It is considerably shorter and simpler than the older methods and provides BaP in higher overall yield.

PYRROLO SULFONAMIDE COMPOUNDS FOR MODULATION OF ORPHAN NUCLEAR RECEPTOR RAR-RELATED ORPHAN RECEPTOR-GAMMA (RORGAMMA, NR1F3) ACTIVITY AND FOR THE TREATMENT OF CHRONIC INFLAMMATORY AND AUTOIMMUNE DISEASES

The invention provides modulators for the orphan nuclear receptor RORy and methods for treating RORy mediated diseases by administrating these novel RORy modulators to a human or a mammal in need thereof. Specifically, the present invention provides pyrrolo sulfonamide compounds of Formula (1) and the enantiomers, diastereomers, tautomers, solvates and pharmaceutically acceptable salts thereof.

Bronsted base-assisted boronic acid catalysis for the dehydrative intramolecular condensation of dicarboxylic acids

Bronsted base-assisted boronic acid catalysis for the dehydrative self-condensation of carboxylic acids is described. Arylboronic acid bearing bulky (N,N-dialkylamino)methyl groups at the 2,6-positions can catalyze the intramolecular dehydrative condensation of di-and tetracarboxylic acids. This is the first successful method for the catalytic dehydrative self-condensation of carboxylic acids.(Figure Presented)