2501-37-3Relevant articles and documents
Reactions of 1-acylamino-1-(trimethylsiloxy)alkanes: Versatile precursors to acylimines
Johnson, A. Peter,Luke, Richard W. A.,Boa, Andrew N.
, p. 895 - 905 (2007/10/03)
1-Acylamino-1-(trimethylsiloxy)alkanes react with carbon and heteroatom nucleophiles to give the corresponding 1-substituted-1-acylaminoalkanes. The 1-acylamino-1-(trimethylsiloxy)alkanes can also give rise to enamides, and by this route the mild antibiotic tuberin, and the isomeric (Z)-tuberin have been prepared. A further example of their reactions is illustrated with the acid-catalysed intramolecular cyclisation onto a carbon-carbon double bond. These transformations show that 1-acylamino-1-(trimethylsiloxy)alkanes are versatile precursors to synthetically useful acylimines.
Total synthesis of erbstatin analogs
-
, (2008/06/13)
The present invention relates to a new process for the preparation of Erbstatin and Erbstatin analogs, which can be represented by the following formula (I) STR1 wherein R is hydrogen, a lower alkyl or a lower alkanoyl group; n is an integer of 1 to 3; A is --CH=CH-- or --CH2 --CH2 --; R1 is hydrogen or a lower alkyl group, and R2 is a hydrogen or halogen atom.