25016-17-5Relevant articles and documents
Synthesis of 2,2,2-trifluoroethyl 1H-pyrazole carboxylates: Insight into the mechanism of trichloromethyl group hydrolysis
Gon?alves, Helena A.,Pereira, Bruna A.,Teixeira, Wystan K.O.,Moura, Sidnei,Flores, Darlene C.,Flores, Alex F.C.
, p. 40 - 45 (2016)
This paper reports one-pot synthesis of 2,2,2-trifluoroethyl 1H-pyrazole-5(3)-carboxylates via cyclocondensation of 1,1,1-trichloro-4-alkoxy-3-alken-2-ones [Cl3CC(O)C(R2) = C(R1)OMe, where R1 = H, CH3
Heteroaromatic Carboxamide Derivatives as Plasma Kallikrein Inhibitors
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Paragraph 0254; 0258; 0259; 0260, (2020/03/01)
Heteroaromatic carboxamides of formula (I), wherein Y, R, and X are as defined herein, and pharmaceutically acceptable salts thereof. The compounds of formula (I) can be used in methods for the treatment of diseases which can be influenced by inhibition of plasma kallikrein.
A 3 - methyl -5 - pyrazole carboxylic acid dimethyl ester chemical synthesis method
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Paragraph 0019; 0026-0028; 0036; 0037; 0045, (2019/01/22)
The invention relates to a chemical synthesis method of methyl 3-methyl-5-pyrazolylformate.3-methylpyrazole used as the raw material is subjected to reactive hydrogen protection, carboxylation, esterification and deprotection to prepare the methyl 3-methy