25017-47-4

Basic information

• Product Name: (3,4-Dimethoxyphenethyl)urea
• Synonyms: (3,4-Dimethoxyphenethyl)urea;1-(3,4-Dimethoxyphenethyl)urea
• CAS NO: 25017-47-4
• Molecular Formula: C₁₁H₁₆N₂O₃
• Molecular Weight: 224.26
• Mol File: 25017-47-4.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 367.6°C at 760 mmHg
• Flash Point: 176.1°C
• Appearance: /
• Density: 1.141g/cm³
• Vapor Pressure: 1.35E-05mmHg at 25°C
• Refractive Index: 1.533
• CAS DataBase Reference: (3,4-Dimethoxyphenethyl)urea(CAS DataBase Reference)
• NIST Chemistry Reference: (3,4-Dimethoxyphenethyl)urea(25017-47-4)
• EPA Substance Registry System: (3,4-Dimethoxyphenethyl)urea(25017-47-4)

Safety Data

• Hazardous Substances Data: 25017-47-4(Hazardous Substances Data)

Usage

Description

(3,4-Dimethoxyphenethyl)urea, also known as 3,4-Dimethoxyphenethylurea, is a chemical compound with the molecular formula C11H16N2O3. It is a urea derivative with two methoxy groups attached to the phenethyl moiety. (3,4-Dimethoxyphenethyl)urea has potential applications in the field of medicinal chemistry and pharmaceuticals due to its structural features and ability to interact with biological systems.

Uses

Used in Medicinal Chemistry and Pharmaceuticals:
(3,4-Dimethoxyphenethyl)urea is used as a building block in the synthesis of more complex organic compounds for medicinal chemistry and pharmaceuticals. Its unique structure allows it to interact with biological systems, making it a promising candidate for the development of new drugs and therapeutic agents.
Used in Research and Development:
(3,4-Dimethoxyphenethyl)urea is used as a research tool in the study of biological processes and drug development. Its potential applications and properties are not yet fully understood, and further research and investigation are necessary to explore its capabilities and maximize its potential in various fields.
Note: The specific applications and industries for (3,4-Dimethoxyphenethyl)urea are not provided in the materials. The uses mentioned above are based on its potential applications in medicinal chemistry, pharmaceuticals, and research and development. Further information may be needed to identify specific industries and application types.

InChI:InChI=1/C11H16N2O3/c1-15-9-4-3-8(7-10(9)16-2)5-6-13-11(12)14/h3-4,7H,5-6H2,1-2H3,(H3,12,13,14)

Upstream product

• 35167-81-8 3,4-dimethoxyphenethyl isocyanate 
• 590-28-3 potassium cyanate 
• 120-20-7 2-(3,4-dimethoxyphenyl)-ethylamine 
• 635-85-8 homoveratrylamine hydrochloride 
• 57-13-6 urea 
• 598-55-0 methyl carbamate 
• 51842-87-6 3-(3,4-dimethoxy-phenyl)-propionyl chloride 
• 2107-70-2 3,4-methoxycinnamic acid 
• 21997-97-7 3-(3,4-dimethoxy-phenyl)-propionyl azide 

Downstream Products

• 92764-05-1 1-<2-(3,4-dimethoxyphenethyl)>imidazolidine-2,4,5-trione 
• 75535-95-4 1-<2-(3,4-Dimethoxyphenyl)ethyl>pyrimidin-2,4,6(1H,3H,5H)-trion 
• 128043-76-5 ethyl 1-(2-(3,4-dimethoxyphenyl)ethyl)-2,4,5-trioxoimidazolidine-3-acetate 
• 91210-08-1 2-(2,6-Difluoro-phenylamino)-9,10-dimethoxy-6,7-dihydro-pyrimido[6,1-a]isoquinolin-4-one 
• 76536-29-3 2-Cyclohexylamino-9,10-dimethoxy-6,7-dihydro-pyrimido[6,1-a]isoquinolin-4-one 
• 91209-81-3 9,10-dimethoxy-2-phenoxy-6,7-dihydro-4H-pyrimido<6,1-a>isoquinolin-4-one 
• 76536-47-5 2-(3,5-Dimethyl-phenylamino)-9,10-dimethoxy-6,7-dihydro-pyrimido[6,1-a]isoquinolin-4-one 
• 76536-43-1 2-(3,4-Dimethyl-phenylamino)-9,10-dimethoxy-6,7-dihydro-pyrimido[6,1-a]isoquinolin-4-one 
• 91210-00-3 2-(4-Hydroxy-phenylamino)-9,10-dimethoxy-6,7-dihydro-pyrimido[6,1-a]isoquinolin-4-one 
• 76536-44-2 2-(4-Chloro-phenylamino)-9,10-dimethoxy-6,7-dihydro-pyrimido[6,1-a]isoquinolin-4-one 
• 76536-53-3 2-(2-Ethyl-phenylamino)-9,10-dimethoxy-6,7-dihydro-pyrimido[6,1-a]isoquinolin-4-one 
• 76536-49-7 9,10-dimethoxy-2-(2,4-dimethylanilino)-6,7-dihydro-4H-pyrimido-(6,1-a)-isoquinolin-4-one 
• 91210-10-5 2-(3-Amino-4-methyl-phenylamino)-9,10-dimethoxy-6,7-dihydro-pyrimido[6,1-a]isoquinolin-4-one 
• 76536-45-3 9,10-dimethoxy-2-(2,6-dimethylanilino)-6,7-dihydro-4H-pyrimido-(6,1-a)-isoquinolin-4-one 

Relevant articles and documents

Ammonium Chloride-Promoted Rapid Synthesis of Monosubstituted Ureas under Microwave Irradiation

Monosubstituted ureas are important scaffolds in organic chemistry. They appear in various biologically active compounds and serve as versatile precursors in synthesis. Monosubstituted ureas were originally prepared using toxic and hazardous phosgene equivalents. Modern methods include transamidation of urea and nucleophilic addition to cyanate salts, both of which suffer from a narrow substrate scope due to the need for a strong acid and prolonged reaction times. We hereby report that ammonium chloride can promote the reaction between amines and potassium cyanate to generate monosubstituted ureas in water. This method proceeds rapidly under microwave irradiation and tolerates a broad range of functional groups. Unlike previous strategies, it is compatible with other nucleophiles, acid-labile moieties, and most of the common protecting groups. The products precipitate out of solution, allowing facile isolation without column chromatography.

Highly selective aldose reductase inhibitors. 1. 3-(Arylalkyl)-2,4,5- trioxoimidazolidine-1-acetic acids

A series of 3-(arylalkyl)-2,4,5-trioxoimidazolidine-1-acetic acids (1) was prepared and tested for aldose reductase (AR) and aldehyde reductase (ALR) inhibitory activities. These compounds showed strong inhibitory activity against AR without significant inhibitory activity for ALR. The ratio of IC50(ALR)IC50(AR) was > 1000 in some compounds. On the basis of pharmacological tests such as the recovery of reduced motor nerve conduction velocity and toxicological profile, 3-(3-nitrobenzyl)-2,4,5- trioxoimidazolidine-1-acetic acid (NZ-314) was selected as the candidate for clinical development.