250213-79-7

Basic information

• Product Name: 2-Chloro-5-(4-fluorophenyl)-1H-pyrrole-3-carboxylic acid
• Synonyms: 2-Chloro-5-(4-fluorophenyl)-1H-pyrrole-3-carboxylic acid
• CAS NO: 250213-79-7
• Molecular Weight: 239.633
• Mol File: 250213-79-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-Chloro-5-(4-fluorophenyl)-1H-pyrrole-3-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Chloro-5-(4-fluorophenyl)-1H-pyrrole-3-carboxylic acid(250213-79-7)
• EPA Substance Registry System: 2-Chloro-5-(4-fluorophenyl)-1H-pyrrole-3-carboxylic acid(250213-79-7)

Safety Data

• Hazardous Substances Data: 250213-79-7(Hazardous Substances Data)

Upstream product

• 131952-81-3 Ethyl 2-cyano-4-(4-fluorophenyl)-4-oxobutanoate 
• 250213-69-5 Ethyl 2-chloro-5-(4-fluorophenyl)-1H-pyrrole-3-carboxylate 
• 456-04-2 2-Chloro-4'-fluoroacetophenone 

Relevant articles and documents

Synthesis and dopamine D2-like receptor binding affinity of substituted 5-phenyl-pyrrole-3-carboxamides.

A series of 5-p-substituted phenyl-pyrrole-3-carboxamide derivatives was designed as hybrid analogs of the dopamine D2-like 5-phenyl-pyrrole and heterocyclic carboxamide antipsychotics. The title compounds were synthesized and evaluated for dopamine D2-like receptor by means of [3H]YM-09151-2 receptor binding assay. The compound bearing a 1-ethyl-2-methyl-pyrrolidine moiety as the basic part of 5-phenyl-pyrrole-3-carboxamide derivative 1a together with its 2-chloro analog 1f were found to possess affinity in the low micromolar range. Substituted phenyl-pyrrolecarboxamides containing groups such as F, Cl, NO2, CH3, at the 4-position of the phenyl ring, gave ligands with lower D2-like affinity.