25027-33-2

Basic information

• Product Name: Benzene, 1-(1,1-dimethylethyl)-4-(1-methylpropyl)-
• Synonyms: Benzene,1-(1,1-dimethylethyl)-4-(1-methylpropyl);1-sec-butyl-4-tert-butyl-benzene;1-sec-Butyl-4-tert-butyl-benzol;p-(sec-Butyl)-tert-butylbenzol;4-[4-(Trifluoromethyl)phenyl]-4,5-dihydro-3H-isoxazolo[3,4,5-kl]acridine;4-tert-butyl-1-sec-butylbenzene
• CAS NO: 25027-33-2
• Molecular Formula: C14H22
• Molecular Weight: 190.329
• Mol File: 25027-33-2.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: Benzene, 1-(1,1-dimethylethyl)-4-(1-methylpropyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzene, 1-(1,1-dimethylethyl)-4-(1-methylpropyl)-(25027-33-2)
• EPA Substance Registry System: Benzene, 1-(1,1-dimethylethyl)-4-(1-methylpropyl)-(25027-33-2)

Safety Data

• Hazardous Substances Data: 25027-33-2(Hazardous Substances Data)

Upstream product

• 253185-03-4 tert-butylbenzene 
• 71-36-3 butan-1-ol 
• 74-85-1 ethene 
• 120-12-7 anthracene 
• 3972-56-3 4-(tert-butyl)chlorobenzene 
• 598-30-1 sec.-butyllithium 
• 1228105-34-7 1-(1,1-dimethylethyl)-4-(1-methylenepropyl)benzene 
• 71-43-2 benzene 
• 3972-65-4 1-bromo-4-tert-butylbenzene 
• 74133-06-5 sec-butyl zinc chloride 
• 78-86-4 s-butyl chloride 
• 78-83-1 2-methyl-propan-1-ol 
• 135-98-8 sec-Butylbenzene 

Downstream Products

• 87-82-1 hexabromobenzene 

Relevant articles and documents

Efficient Pd-Catalyzed Direct Coupling of Aryl Chlorides with Alkyllithium Reagents

Organolithium compounds are amongst the most important organometallic reagents and frequently used in difficult metallation reactions. However, their direct use in the formation of C?C bonds is less established. Although remarkable advances in the coupling of aryllithium compounds have been achieved, Csp2?Csp3 coupling reactions are very limited. Herein, we report the first general protocol for the coupling or aryl chlorides with alkyllithium reagents. Palladium catalysts based on ylide-substituted phosphines (YPhos) were found to be excellently suited for this transformation giving high selectivities at room temperature with a variety of aryl chlorides without the need for an additional transmetallation reagent. This is demonstrated in gram-scale synthesis including building blocks for materials chemistry and pharmaceutical industry. Furthermore, the direct coupling of aryllithiums as well as Grignard reagents with aryl chlorides was also easily accomplished at room temperature.

Air stable, sterically hindered ferrocenyl dialkylphosphines for palladium-catalyzed C-C, C-N, and C-O bond-forming cross-couplings

Pentaphenylferrocenyl di-tert-butylphosphine has been prepared in high yield from a two-step synthetic procedure, and the scope of various cross-coupling processes catalyzed by complexes bearing this ligand has been investigated. This ligand creates a remarkably general palladium catalyst for aryl halide amination and for Suzuki coupling. Turnovers of roughly 1000 were observed for aminations with unactivated aryl bromides or chlorides. In addition, complexes of this ligand catalyzed the formation of selected aryl ethers under mild conditions. The reactions encompassed electron-rich and electron-poor aryl bromides and chlorides. In the presence of catalysts containing this ligand, these aryl halides coupled with acyclic or cyclic secondary alkyl- and arylamines, with primary alkyl- and arylamines, and with aryl- and primary alkylboronic acids. These last couplings provide the first general procedure for reaction of terminal alkylboronic acids with aryl halides without toxic or expensive bases. The ligand not only generates highly active palladium catalysts, but it is air stable in solution and in the solid state. Palladium(0) complexes of this ligand are also air stable as a solid and react only slowly with oxygen in solution.