250371-94-9

Basic information

• Product Name: 4-(4-ethyl-piperidin-1-yl)-3-fluoro-phenylamine
• Synonyms: 4-(4-ethyl-piperidin-1-yl)-3-fluoro-phenylamine
• CAS NO: 250371-94-9
• Molecular Weight: 222.306
• Mol File: 250371-94-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-(4-ethyl-piperidin-1-yl)-3-fluoro-phenylamine(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(4-ethyl-piperidin-1-yl)-3-fluoro-phenylamine(250371-94-9)
• EPA Substance Registry System: 4-(4-ethyl-piperidin-1-yl)-3-fluoro-phenylamine(250371-94-9)

Safety Data

• Hazardous Substances Data: 250371-94-9(Hazardous Substances Data)

Upstream product

• 369-34-6 3,4-difluoronitrobenzene 
• 3230-23-7 4-ethylpiperidine 
• 250371-82-5 4-ethyl-1-(2-fluoro-4-nitro-phenyl)-piperidine 

Downstream Products

• 250372-44-2 Methanesulfonic acid (R)-3-[4-(4-ethyl-piperidin-1-yl)-3-fluoro-phenyl]-2-oxo-oxazolidin-5-ylmethyl ester 
• 250373-02-5 (R)-5-Azidomethyl-3-[4-(4-ethyl-piperidin-1-yl)-3-fluoro-phenyl]-oxazolidin-2-one 
• 268209-39-8 (R)-3-[4-(4-Ethyl-piperidin-1-yl)-3-fluoro-phenyl]-5-isothiocyanatomethyl-oxazolidin-2-one 
• 250373-44-5 (S)-5-Aminomethyl-3-[4-(4-ethyl-piperidin-1-yl)-3-fluoro-phenyl]-oxazolidin-2-one 
• 250372-24-8 (R)-3-[4-(4-Ethyl-piperidin-1-yl)-3-fluoro-phenyl]-5-hydroxymethyl-oxazolidin-2-one 

Relevant articles and documents

Structure-activity relationship (SAR) studies on oxazolidinone antibacterial agents. 2.1) Relationship between lipophilicity and antibacterial activity in 5-thiocarbonyl oxazolidinones

5-Thiourea and 5-dithiocarbamate oxazolidinones were synthesized as a continuation of research on 5-thiocarbonyl oxazolidinone antibacterial agents considering the hydrophobic parameters of the molecule. The structure-activity relationship (SAR) study revealed that the antibacterial activity on 5-thiocarbonyl oxazolidinones was significantly affected by the lipophilicity, especially the calculated log P value and the balance between 5-hydrophilic (or hydrophobic) substituent and hydrophobic (or hydrophilic) substituents on the benzene ring. Some of 5-thiocarbonyl oxazolidinones were found to have good in vitro antibacterial activity against gram-positive bacteria including methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant enterococci (VRE).