25040-17-9Relevant articles and documents
Facile and simple synthesis of N -alkyl and N -aryl 2-benzazepines by nucleophilic heteroannulation
Srinivasan,Rajashekar,Shyamapada,Syam Kumar
supporting information, p. 3112 - 3121 (2015/10/12)
An efficient and practical synthesis of N-alkyl and N-aryl 2-benzazepine has been developed. The key steps involved in the synthesis were palladium-mediated Heck reaction followed by aza heterocyclic ring construction by nucleophilic heteroannulation. This four-step sequence synthetic protocol gave moderate to good yields for a wide range of substrates. Subsequently, functionalization of the synthesized compound was carried out under Heck and Suzuki reaction conditions.
Solvent effect in reactions using strykers reagent
Sass, Daiane Cristina,Heleno, Vladimir Constantino Gomes,Cavalcante, Simone,Da Silva Barbosa, Jader,Soares, Ana Carolina Ferreira,Constantino, Mauricio Gomes
, p. 9374 - 9378 (2013/01/15)
The solvent has a significant influence in the rate of reactions promoted by Strykers reagent. The reactions performed in THF were, in most cases, faster than in toluene.
New synthetic methodology for construction of the 3,4-dihydroisoquinolinone skeleton: A key structure for isoquinoline alkaloids
Muejde, Berk,Oezcan, Sevil,Balci, Metin
, p. 407 - 410 (2012/04/10)
We hereby report a new method for preparation of 3,4-dihydroisoquinolin- 1(2H)-one as well as isoquinolin-1(2H)-one skeleton starting from the methyl 2-(3-methoxy-3-oxopropyl)benzoate. The ester functionality, adjacent to the methylene, was regiospecifically converted to the desired acyl azide. The isocyanate was transformed into the monoisocyanate by Curtius rearrangement followed by trapping with aniline. The formed urea derivative was cyclized with NaH to give a 3,4-dihydroisoquinolin-1(2H)-one derivative. Incorporation of a double bond into the six-membered ring followed by removal of the substituent resulted in the formation of isoquinolin-1(2H)-one skeleton.
