250684-63-0

Basic information

• Product Name: tert-butyl 4-nitrosobenzoate
• Synonyms: tert-butyl 4-nitrosobenzoate
• CAS NO: 250684-63-0
• Molecular Weight: 207.229
• Mol File: 250684-63-0.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: tert-butyl 4-nitrosobenzoate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl 4-nitrosobenzoate(250684-63-0)
• EPA Substance Registry System: tert-butyl 4-nitrosobenzoate(250684-63-0)

Safety Data

• Hazardous Substances Data: 250684-63-0(Hazardous Substances Data)

Upstream product

• 19756-72-0 tert-butyl 4-nitrobenzoate 
• 18144-47-3 tert-butyl 4-aminobenzoate 
• 62-23-7 4-nitro-benzoic acid 

Relevant articles and documents

Activation of Sirtuin 2 Inhibitors Employing Photoswitchable Geometry and Aqueous Solubility

Because isoenzymes of the experimentally and therapeutically extremely relevant sirtuin family show high similarity, addressing the unique selectivity pocket of sirtuin 2 is a promising strategy towards selective inhibitors. An unrelated approach towards selective inhibition of isoenzymes with varied tissue distribution is targeted drug delivery or spatiotemporal activation by photochemical activation. Azologization of two nicotinamide-mimicking lead structures was undertaken to combine both approaches and yielded a set of 33 azobenzenes and azopyridines that have been evaluated for their photochemical behaviour and bioactivity. For some compounds, inhibitory activity reached the sub-micromolar range in their thermodynamically favoured E form and could be decreased by photoisomerization to the metastable Z form. Besides, derivatization with long-chain fatty acids yielded potent sirtuin 2 inhibitors, featuring another intriguing aspect of azo-based photoswitches. In these compounds, switching to the Z isomer increased aqueous solubility and thereby enhanced biological activity by up to a factor of 21. The biological activity of two compounds was confirmed by hyperacetylation of sirtuin specific histone proteins in a cell-based activity assay.

Electronic Decoupling in C3-Symmetrical Light-Responsive Tris(Azobenzene) Scaffolds: Self-Assembly and Multiphotochromism

We report the synthesis of a novel C3-symmetrical multiphotochromic molecule bearing three azobenzene units at positions 1, 3, 5 of the central phenyl ring. The unique geometrical design of such a rigid scaffold enables the electronic decouplin