25100-91-8

Basic information

• Product Name: 2-(4-Chlorophenyl)-4-methylthiazole
• Synonyms: 2-(4-Chlorophenyl)-4-methylthiazole
• CAS NO: 25100-91-8
• Molecular Formula: C₁₀H₈ClNS
• Molecular Weight: 209.7
• Mol File: 25100-91-8.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-(4-Chlorophenyl)-4-methylthiazole(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-Chlorophenyl)-4-methylthiazole(25100-91-8)
• EPA Substance Registry System: 2-(4-Chlorophenyl)-4-methylthiazole(25100-91-8)

Safety Data

• Hazardous Substances Data: 25100-91-8(Hazardous Substances Data)

Usage

Structure

Thiazole ring with a 4-methyl group and a 4-chlorophenyl group attached

Usage

Building block in the synthesis of various drugs and biologically active molecules in the pharmaceutical industry

Potential properties

Antimicrobial, antifungal, and anticancer

Inhibitory effects

On the oxidative pathways in biological systems

Fields of interest

Pharmaceuticals, agriculture, and chemical research

Upstream product

• 78-95-5 chloroacetone 
• 2521-24-6 4-chlorothiobenzamide 
• 693-95-8 4-Methylthiazole 
• 637-87-6 1-Chloro-4-iodobenzene 
• 598-31-2 1-bromoacetone 

Relevant articles and documents

Relative hepatotoxicity of 2-(substituted phenyl)thiazoles and substituted thiobenzamides in mice: Evidence for the involvement of thiobenzamides as ring cleavage metabolites in the hepatotoxicity of 2-phenylthiazoles

The hepatotoxicity of the 3 isomers of para-substituted thiobenzamides and the 3 isomers of 2-(para-substituted phenyl)-4-methylthiazoles was evaluated in mice depleted of glutathione (GSH) by pretreatment with buthionine sulfoximine (BSO). In accordance

Pd/Cu-cocatalyzed reigoselective arylation of thiazole derivatives at 2-position under ligand-free conditions

An efficient protocol for regioselective arylation of thiazole derivatives at the 2-position via palladium- and copper-catalyzed C-H bond activation under ligand-free conditions has been developed. The reaction proceeds smoothly with 1% palladium catalyst in the presence of 20% Cu(TFA)2 to furnish the desired products. The direct C-H arylation and no ligand made this method synthetically useful for the arylation of thiazoles at the 2-position.