25102-89-0

Basic information

• Product Name: Dimethyl-1,2-propyl-phenylaethyl-amin
• Synonyms: Dimethyl-1,2-propyl-phenylaethyl-amin
• CAS NO: 25102-89-0
• Molecular Weight: 191.316
• Mol File: 25102-89-0.mol
• Article Data: 10

Chemical Properties

• CAS DataBase Reference: Dimethyl-1,2-propyl-phenylaethyl-amin(CAS DataBase Reference)
• NIST Chemistry Reference: Dimethyl-1,2-propyl-phenylaethyl-amin(25102-89-0)
• EPA Substance Registry System: Dimethyl-1,2-propyl-phenylaethyl-amin(25102-89-0)

Safety Data

• Hazardous Substances Data: 25102-89-0(Hazardous Substances Data)

Upstream product

• 31502-94-0 (R)-1,2-dimethylpropylidene(1-phenylethyl)amine 
• 3886-69-9 (R)-1-phenyl-ethyl-amine 
• 563-80-4 3-methyl-butan-2-one 
• 167467-26-7 [1,2-Dimethyl-prop-(E)-ylidene]-((R)-1-phenyl-ethyl)-amine 
• 2627-86-3 (S)-1-phenyl-ethylamine 
• 676-58-4 methylmagnesium chloride 
• 78-84-2 isobutyraldehyde 
• 217473-24-0 (S)-1,2-dimethylpropylidene(1-phenylethyl)amine 
• 69128-54-7 (R,S)-α-phenylethylammonium perchlorate 

Downstream Products

• 598-74-3 (2R)-3-methyl-2-butylamine 
• 101689-08-1 (R)-N-((R)-1,2-Dimethyl-propyl)-3,3,3-trifluoro-2-methoxy-2-phenyl-propionamide 

Relevant articles and documents

PROCESS FOR PREPARING AMINE COMPOUND

The present invention aims to provide a practical process for preparing amine compounds through a generalized highly-diastereoselective reductive amination reaction. The present invention relates to a process for diastereoselectively preparing an amine co

A convenient, highly stereoselective, metal-free synthesis of chiral amines

A low cost, efficient, metal-free highly stereoselective reduction of ketimines to chiral amines was developed. Different imines bearing a very cheap and removable chiral auxiliary were reduced simply by trichlorosilane in the presence of N,N-dimethylformamide, often in quantitative yield and complete control of the absolute stereochemistry, to afford highly enantiomerically enriched amines. Georg Thieme Verlag Stuttgart.

Ytterbium acetate promoted asymmetric reductive amination: Significantly enhanced stereoselectivity

(Chemical Equation Presented) Reductive amination of prochiral unhindered 2-alkanones 1 with (R)- or (S)-α-MBA in the presence of Yb(OAc) 3 (50-110 mol %), Raney-Ni, and hydrogen (120 psi) results in increased diastereoselectivity for the amine products 2 (80-89% de) with good yield (80-87%). The increased de is based on comparison with the best previously reported de's when using (R)- or (S)-α-MBA, regardless of the strategy employed [stepwise (isolation of ketimines) or one-pot (reductive amination)], reducing agent examined, or achiral Lewis acid or Bronsted acid examined. An in situ cis- to trans-ketimine isomerization mechanism, promoted by Yb(OAc)3, has been proposed to account for the observed increase in diastereoselectivity and suggests a new entry into the control of ketimine geometry.