251113-21-0 Usage
Description
(E)-1-m-tolylethanone oxime, also known as 3-methylbenzaldoxime, is a chemical compound characterized by its molecular formula C9H11NO. It presents as a yellow crystalline solid and is recognized for its diverse industrial applications, primarily as a building block in the synthesis of other organic compounds. This versatile compound also serves as a reagent in organic chemical reactions, particularly in the conversion of ketones to oximes. Furthermore, (E)-1-m-tolylethanone oxime has demonstrated potential in the pharmaceutical sector, showing promise in the development of innovative drugs and medications. Despite its relatively low solubility in water, this compound has garnered significant interest across various domains of chemistry and pharmaceutical research.
Uses
Used in Chemical Synthesis:
(E)-1-m-tolylethanone oxime is used as a building block for the synthesis of other organic compounds, playing a crucial role in the creation of a wide range of chemical products.
Used in Organic Chemical Reactions:
(E)-1-m-tolylethanone oxime is utilized as a reagent, particularly in the conversion of ketones to oximes, which is an essential process in organic chemistry.
Used in Pharmaceutical Research:
(E)-1-m-tolylethanone oxime is employed in the development of new drugs and medications, contributing to the advancement of pharmaceutical applications and potentially leading to the discovery of novel therapeutic agents.
Used in Industrial Applications:
(E)-1-m-tolylethanone oxime is used across various industries, leveraging its unique properties and reactivity to contribute to the production of a multitude of products and materials.
Check Digit Verification of cas no
The CAS Registry Mumber 251113-21-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,5,1,1,1 and 3 respectively; the second part has 2 digits, 2 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 251113-21:
(8*2)+(7*5)+(6*1)+(5*1)+(4*1)+(3*3)+(2*2)+(1*1)=80
80 % 10 = 0
So 251113-21-0 is a valid CAS Registry Number.
251113-21-0Relevant articles and documents
C3-Arylation of indoles with aryl ketonesviaC-C/C-H activations
Dai, Hui-Xiong,Guo, Zi-Qiong,Ma, Biao,Wang, Xing,Wang, Zhen-Yu,Xu, Hui
supporting information, p. 9716 - 9719 (2021/09/30)
C3-Arylation of indoles with aryl ketones is accomplishedviapalladium-catalyzed ligand-promoted Ar-C(O) cleavage and subsequent C-H arylation of indole. Various (hetero)aryl ketones are compatible in this reaction, affording the corresponding 3-arylindoles in moderate to good yields. Further introduction of an indole moiety into the natural products desoxyestrone and evodiamine demonstrate the synthetic utility of this protocol.
PRODUCTION METHOD OF KETOXIME COMPOUND
-
Paragraph 0022-0024, (2017/10/11)
PROBLEM TO BE SOLVED: To provide a new catalytic production method of a ketoxime that does not directly use hydroxyamine, nor require severe reaction conditions. SOLUTION: A production method of a ketoxime compound includes a step for transoximizing a ketone compound and ethyl acetohydroxamate in the presence of an organic solvent and a trifluoromethanesulfonic acid metal salt. The trifluoromethanesulfonic acid metal salt is preferably scandium (III) trifluoromethanesulfonate. The organic solvent is preferably methylene chloride, methanol, ethanol, n-propanol, or n-butanol. SELECTED DRAWING: None COPYRIGHT: (C)2017,JPOandINPIT
Intermolecular cope-type hydroamination of alkenes and alkynes
Beauchemin, Andre M.,Moran, Joseph,Lebrun, Marie-Eve,Seguin, Catherine,Dimitrijevic, Elena,Zhang, Lili,Gorelsky, Serge I.
, p. 1410 - 1413 (2008/12/23)
(Chemical Equation Presented) Keep it simple! Intermolecular hydroamination can be achieved simply upon heating alkynes and alkenes with aqueous hydroxylamine. Alkynes react to afford oximes in good to excellent yields, and the formation of Markovnikov products is favored. A mechanism involving Cope-type hydroamination followed by bimolecular proton transfer is suggested and supported by DFT studies.
