251300-28-4

Basic information

• Product Name: 5-BROMO-3-FLUOROSALICYLALDEHYDE
• Synonyms: 5-BROMO-3-FLUOROSALICYLALDEHYDE;5-BROMO-3-FLUORO-2-HYDROXYBENZALDEHYDE;5-BROMO-3-FLUORO-2-HYDROXYBENZENECARBALDEHYDE;5-Bromo-3-fluoro-2-hydroxybenzaldehyde 97%;5-Bromo-3-fluorosalicylaldehyde, 4-Bromo-2-fluoro-6-formylphenol;5-BroMo-3-fluorosalicylaldehyde;5-Bromo-3-fluoro-2-hydroxybenzaldehyde97%
• CAS NO: 251300-28-4
• Molecular Formula: C₇H₄BrFO₂
• Molecular Weight: 219.01
• EINECS: 1533716-785-6
• Product Categories: Aldehydes;C7;Carbonyl Compounds;Aryl Fluorinated Building Blocks;Building Blocks;Carbonyl Compounds;Chemical Synthesis;Fluorinated Building Blocks;Organic Building Blocks;Organic Fluorinated Building Blocks;Other Fluorinated Organic Building Blocks
• Mol File: 251300-28-4.mol
• Article Data: 11

Chemical Properties

• Melting Point: 112-116 °C(lit.)
• Boiling Point: 226.0±35.0 °C(Predicted)
• Appearance: /
• Density: 1.826±0.06 g/cm3(Predicted)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 6.36±0.23(Predicted)
• CAS DataBase Reference: 5-BROMO-3-FLUOROSALICYLALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-BROMO-3-FLUOROSALICYLALDEHYDE(251300-28-4)
• EPA Substance Registry System: 5-BROMO-3-FLUOROSALICYLALDEHYDE(251300-28-4)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• Hazardous Substances Data: 251300-28-4(Hazardous Substances Data)

Usage

General Description

5-Bromo-3-Fluorosalicylaldehyde is a synthetic, organic compound that is primarily used in the field of chemistry as an intermediate and reagent. This chemical is known for its aromatic nature and falls under the classification of bromofluorochemicals, featuring characteristics of both bromine and fluorine elements in its structure. It's generally used for research and development purposes. Since it's reactive and sensitive, handling requires stringent safety measures. Its molecular formula is C7H4BrFO2 and it forms a white to pale yellow solid in its purest form. Not much is known about its hazards or toxicity because it's mostly used in controlled, laboratory settings.

Upstream product

• 2105-94-4 4-bromo-2-fluorophenol 
• 100-97-0 hexamethylenetetramine 
• 394-50-3 3-fluorosalicylaldehyde 

Downstream Products

• 251300-29-5 5-bromo-3-fluoro-2-hydroxybenzoic acid 
• 1003298-75-6 2-(benzyloxy)-5-bromo-3-fluorobenzaldehyde 
• 341-27-5 3-fluorosalicylic acid 
• 470668-70-3 5-bromo-3-fluoro-2-methoxybenzaldehyde 
• 876861-29-9 5-bromo-3-fluoro-benzene-1,2-diol 
• 773873-15-7 4-bromo-2-fluoro-6-(hydroxymethyl)phenol 
• 286836-04-2 5-bromo-7-fluoro-1-benzofuran 
• 1249506-21-5 5-bromo-7-fluoro-1-benzofuran-2-carboxylic acid 
• 1415003-54-1 5-bromo-2-(but-3-enyloxy)-3-fluorobenzaldehyde 
• 1415003-55-2 2-(but-3-enyloxy)-3-fluoro-5-(pyrimidin-5-yl)benzaldehyde 

Relevant articles and documents

An improved method for the synthesis of 3-fluorosalicylic acid with application to the synthesis of 3-(Trifluoromethyl)salicylic acid

An improved method for the synthesis of 3-fluorosalicylic acid is described. A positional protective group strategy allows formylation selectively at the ortho position of 4-bromo-2-fluorophenol. Oxidation of the resulting salicylaldehyde to the salicylic acid, followed by debromination, affords 3-fluorosalicylic acid. The method has also been applied to the synthesis of 3-(trifluoromethyl)salicylic acid.

SUBSTITUTED CONDENSED THIOPHENES AS MODULATORS OF STING

A compound of formula (I), wherein: R1 is selected from (i) H, (ii) C3-6cycloalkyl, (iii) C3-7heterocyclyl optionally substituted with a group selected from: methyl and ester, and (iv) linear or branched C1-4alkyl optionally substituted with a group selected from: alkoxy, amino, amido, acylamido, acyloxy, alkyl carboxyl ester, alkyl carbamoyl, alkyl carbamoyl ester, phenyl, phosphonate ester, C3-7heterocyclyl optionally substituted with a group selected from methyl and oxo, and a naturally occurring amino acid, optionally N-substituted with a group selected from methyl, acetyl and boc; A1 is CRA or N; A2 is CRB or N; A3 is CRC or N; A4 is CRD or N; where no more than two of A1, A2, A3, and A4 may be N; one or two of RA, RB, RC, and RD, (if present) are selected from H, F, Cl, Br, Me, CF3, cyclopropyl, cyano, OMe, OEt, CH2OH, CH2OMe and CH2NMe2; the remainder of RA, RB, RC, and RD, (if present) are H; Y is O, NH or CH2; RY is selected from: (RYA) and (RYB).

GLUCOSYLCERAMIDE SYNTHASE INHIBITORS FOR THE TREATMENT OF DISEASES

Described herein are compounds of Formula I, methods of making such compounds, pharmaceutical compositions and medicaments containing such compounds, and methods of using such compounds to treat or prevent diseases or conditions associated with the enzyme