251454-49-6

Basic information

• Product Name: (2S)-3-[4-(benzyloxy)phenyl]-2-ethoxypropanoic acid
• Synonyms: (2S)-3-[4-(benzyloxy)phenyl]-2-ethoxypropanoic acid
• CAS NO: 251454-49-6
• Molecular Weight: 300.354
• Mol File: 251454-49-6.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: (2S)-3-[4-(benzyloxy)phenyl]-2-ethoxypropanoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (2S)-3-[4-(benzyloxy)phenyl]-2-ethoxypropanoic acid(251454-49-6)
• EPA Substance Registry System: (2S)-3-[4-(benzyloxy)phenyl]-2-ethoxypropanoic acid(251454-49-6)

Safety Data

• Hazardous Substances Data: 251454-49-6(Hazardous Substances Data)

Upstream product

• 251454-48-5 3-(4-benzyloxyphenyl)-(S)-2-ethoxy-N-(2-hydroxy-(R)-1-phenylethyl)propanoic amide 
• 853302-14-4 (Z)-3-(4-(benzyloxy)phenyl)-2-ethoxyacrylic acid 
• 222835-03-2 3-(4-benzyloxy-phenyl)-2-ethoxy-acrylic acid ethyl ester 
• 197299-16-4 ethyl 2-ethoxy-3-(4-hydroxy-phenyl)-propionate 
• 4397-53-9 p-benzyloxybenzaldehyde 
• 251454-47-4 3-[4-(Benzyloxy)phenyl]-2-ethoxypropanoic acid 
• 481072-42-8 3-(4-benzyloxyphenyl)-2-hydroxypropionic acid isopropyl ester 
• 75-03-6 ethyl iodide 
• 3561-85-1 sodium tert-pentoxide 
• 223126-28-1 3-(4-benzyloxyphenyl)-2-ethoxypropanoic acid ethyl ester 
• 123-08-0 4-hydroxy-benzaldehyde 
• 100-44-7 benzyl chloride 

Downstream Products

• 222555-06-8 ethyl (2S)-2-ethoxy-3-(4-hydroxyphenyl)propanoate 
• 251454-50-9 ethyl (2S)-3-[4-(benzyloxy)phenyl]-2-ethoxypropanoate 
• 325793-71-3 (S)-2-ethoxy-3-(4-hydroxyphenyl)propanoic acid isopropyl ester 
• 856258-53-2 S-2-ethoxy-3-(4-{R-1-[2-(4-ethylphenyl)ethylcarbamoyl]ethoxy}phenyl)propionic acid isopropyl ester 
• 853302-27-9 S-2-ethoxy-3-[4-(R-1-carboxyethoxy)phenyl]propionic acid isopropyl ester 
• 405271-21-8 2-ethoxy-3-(4-benzyloxyphenyl)propionic acid isopropyl ester 

Relevant articles and documents

Biferrocene-based diphosphine ligands: Synthesis and application of walphos analogues in asymmetric hydrogenations

A total of four biferrocene-based Walphos-type ligands have been synthesized, structurally characterized, and tested in the rhodium-, ruthenium- and iridium-catalyzed hydrogenation of alkenes and ketones. Negishi coupling conditions allowed the biferrocene backbone of these diphosphine ligands to be built up diastereoselectively from the two nonidentical and nonracemic ferrocene fragments (R)-1-(N,N-dimethylamino)ethylferrocene and (SFc)-2- bromoiodoferrocene. The molecular structures of (SFc)-2- bromoiodoferrocene, the coupling product, two ligands, and the two complexes ([PdCl2(L)] and [RuCl(p-cymene)(L)]PF6) were determined by X-ray diffraction. The structural features of complexes and the catalysis results obtained with the newly synthesized biferrocene-based ligands were compared with those of the corresponding Walphos ligands.

Design, synthesis, and structure-activity relationship of carbamate-tethered aryl propanoic acids as novel PPARα/γ dual agonists

We have developed a new class of PPARα/γ dual agonists, which show excellent agonistic activity in PPARα/γ transactivation assay. In particular, (R)-9d was identified as a potent PPARα/γ dual agonist with EC50s of 0.377 μM in PPARα and 0.136 μM in PPARγ, respectively. Interestingly, the structure-activity relationship revealed that the stereochemistry of the identified PPARα/γ dual agonists significantly affects their agonistic activities in PPARα than in PPARγ.

Synthesis of PPAR agonist via asymmetric hydrogenation of a cinnamic acid derivative and stereospecific displacement of (S)-2-chloropropionic acid

(Chemical Equation Presented) The synthesis of the peroxime proliferator activated receptor (PPAR) α,γ-agonist (1) was accomplished with high enantio- and diastereoselectivity by employing an asymmetric hydrogenation strategy, of an α-alkoxy cinnamic acid