251458-15-8

Basic information

• Product Name: Methyl 2-(3-broMophenyl)-2-Methylpropanoate
• Synonyms: Methyl 2-(3-broMophenyl)-2-Methylpropanoate;2-(3-Bromo-phenyl)-2-methyl-propionic acid methyl ester;Benzeneacetic acid, 3-bromo-α,α-dimethyl-, methyl ester
• CAS NO: 251458-15-8
• Molecular Formula: C₁₁H₁₃BrO₂
• Molecular Weight: 257.12372
• Mol File: 251458-15-8.mol
• Article Data: 12

Chemical Properties

• Appearance: /
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: Methyl 2-(3-broMophenyl)-2-Methylpropanoate(CAS DataBase Reference)
• NIST Chemistry Reference: Methyl 2-(3-broMophenyl)-2-Methylpropanoate(251458-15-8)
• EPA Substance Registry System: Methyl 2-(3-broMophenyl)-2-Methylpropanoate(251458-15-8)

Safety Data

• Hazardous Substances Data: 251458-15-8(Hazardous Substances Data)

Usage

General Description

Methyl 2-(3-bromophenyl)-2-methylpropanoate is a synthetic compound used in the production of pharmaceuticals, fragrances, and flavoring agents. It is commonly utilized as an intermediate in organic synthesis and is known for its sweet, fruity odor. This chemical is formed by the esterification of 2-bromo-3-methylbenzoic acid with methanol, and it is commonly used in the pharmaceutical industry as a building block for the synthesis of various drugs and active pharmaceutical ingredients. Additionally, its fruity scent makes it a popular ingredient in the production of perfumes and other scented products.

Upstream product

• 150529-73-0 methyl 2-(3-bromophenyl)acetatee 
• 74-88-4 methyl iodide 
• 90433-20-8 2-(3-bromo-phenyl)-2-methyl-propionitrile 

Downstream Products

• 81606-47-5 2-(3-bromophenyl)-2-methylpropanoic acid 
• 251458-14-7 2-methyl-2-[3-(2-pyridyl)phenyl]propionic acid methyl ester 
• 81606-48-6 2,2-dimethyl-2-(3-bromophenyl)ethanol 
• 849934-93-6 methyl 2-methyl-2-(3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)propanoate 

Relevant articles and documents

COMPOUNDS AND USES THEREOF

The present disclosure features compounds useful for the treatment of BAF complex-related disorders.

4-AMINO-7,8-DIHYDROPYRIDO[4,3-d]PYRIMIDIN-5(6H)-ONE DERIVATIVES

The invention provides compounds of the general Formula (I) where R1, R2, and A are defined herein, as well as the preparation, compositions and uses thereof.

Identification of (R)-1-(5-tert-butyl-2,3-dihydro-1H-inden-1-yl)-3-(1H- indazol-4-yl)urea (ABT-102) as a potent TRPV1 antagonist for pain management

Vanilloid receptor TRPV1 is a cation channel that can be activated by a wide range of noxious stimuli, including capsaicin, acid, and heat. Blockade of TRPV1 activation by selective antagonists is under investigation by several pharmaceutical companies in an effort to identify novel agents for pain management. Here we report that replacement of substituted benzyl groups by an indan rigid moiety in a previously described N-indazole-N′-benzyl urea series led to a number of TRPV1 antagonists with significantly increased in vitro potency and enhanced drug-like properties. Extensive evaluation of pharmacological, pharmacokinetic, and toxicological properties of synthesized analogs resulted in identification of (R)-7 (ABT-102). Both the analgesic activity and drug-like properties of (R)-7 support its advancement into clinical pain trials.