251647-50-4

Basic information

• Product Name: N2-ISOBUTYRYL-5 , O-(4,4 -DIMETHOXYTRITYL)-2 -O-(2
• Synonyms: N2-ISOBUTYRYL-5 , O-(4,4 -DIMETHOXYTRITYL)-2 -O-(2;5'-O-[Bis(4-Methoxyphenyl)phenylMethyl]-2'-O-(2-Methoxyethyl)-N-(2-Methyl-1-oxopropyl)guanosine;N2-iso-Butyroyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-(2-methoxyethyl)guanosine;N-(9-((2R,3R,4R,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-hydroxy-3-(2-methoxyethoxy)tetrahydrofuran-2-yl)-6-oxo-6,9-dihydro-1H-purin-2-yl)isobutyramide;Guanosine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-(2-methoxyethyl)-N-(2-methyl-1-oxopropyl)-
• CAS NO: 251647-50-4
• Molecular Formula: C₃₈H₄₃N₅O₉
• Molecular Weight: 713.77612
• Product Categories: Amines, Aromatics, Pharmaceuticals, Intermediates & Fine Chemicals
• Mol File: 251647-50-4.mol
• Article Data: 6

Chemical Properties

• Melting Point: 112.5-126.6 °C(Solv: hexane (110-54-3))
• Appearance: /
• Density: 1.33±0.1 g/cm3(Predicted)
• PKA: 9.16±0.20(Predicted)
• CAS DataBase Reference: N2-ISOBUTYRYL-5 , O-(4,4 -DIMETHOXYTRITYL)-2 -O-(2(CAS DataBase Reference)
• NIST Chemistry Reference: N2-ISOBUTYRYL-5 , O-(4,4 -DIMETHOXYTRITYL)-2 -O-(2(251647-50-4)
• EPA Substance Registry System: N2-ISOBUTYRYL-5 , O-(4,4 -DIMETHOXYTRITYL)-2 -O-(2(251647-50-4)

Safety Data

• Hazardous Substances Data: 251647-50-4(Hazardous Substances Data)

Usage

Description

N2-ISOBUTYRYL-5, O-(4,4-DIMETHOXYTRITYL)-2-O-(2 is an oligonucleotide analogue, which is a modified form of a naturally occurring nucleotide. It has been synthesized to possess specific properties that make it useful in various applications, particularly in the field of medicine and biotechnology. The compound is characterized by its unique structure, which includes an isobutyryl group at the N2 position, a dimethoxytrityl group at the O5 position, and a 2-methoxyethyl group at the O2 position. These modifications are designed to enhance the stability, solubility, and reactivity of the molecule, making it a versatile tool for research and therapeutic development.

Uses

1. Used in Pharmaceutical Research:
N2-ISOBUTYRYL-5, O-(4,4-DIMETHOXYTRITYL)-2-O-(2 is used as a research tool for the development of new drugs and therapies. Its unique structure allows it to interact with various biological targets, making it a promising candidate for the treatment of a wide range of diseases and conditions.
2. Used in Cancer Treatment:
N2-ISOBUTYRYL-5, O-(4,4-DIMETHOXYTRITYL)-2-O-(2 is being researched for its potential use in the treatment of various types of cancer. Its ability to modulate cellular signaling pathways and interact with key proteins involved in cancer progression makes it a valuable compound for the development of targeted cancer therapies.
3. Used in Drug Delivery Systems:
In the field of drug delivery, N2-ISOBUTYRYL-5, O-(4,4-DIMETHOXYTRITYL)-2-O-(2 is being explored as a component of novel drug delivery systems. Its unique properties, such as enhanced stability and solubility, make it an attractive option for improving the delivery, bioavailability, and therapeutic outcomes of various drugs.
4. Used in Diagnostic Applications:
N2-ISOBUTYRYL-5, O-(4,4-DIMETHOXYTRITYL)-2-O-(2 may also find applications in the development of diagnostic tools and assays. Its ability to interact with specific biological targets can be exploited to design sensitive and specific diagnostic tests for various diseases and conditions.
5. Used in Gene Therapy:
As an oligonucleotide analogue, N2-ISOBUTYRYL-5, O-(4,4-DIMETHOXYTRITYL)-2-O-(2 has potential applications in gene therapy. It can be used to develop gene-silencing or gene-editing strategies, which can be applied to treat genetic disorders or to enhance the functionality of specific genes.

Upstream product

• 40615-36-9 4,4'-dimethoxytrityl chloride 
• 440327-50-4 N²-isobutyryl-2'-O-(2-methoxyethyl)guanosine 
• 2096-10-8 adenosine-2-amine 
• 256224-13-2 2'-O-(2-methoxyethyl)-2,6-diaminopurine riboside 
• 40615-35-8 4,4'-dimethoxytrityl alcohol 
• 100-66-3 methoxybenzene 
• 98-07-7 Benzotrichlorid 

Downstream Products

• 251647-55-9 MOE G amidite 
• 1536203-26-5 C₄₁H₄₆N₆O₉ 

Relevant articles and documents

An improved process for the manufacture of 5′-O-(4,4′-dimethoxytrityl)-N2-isobutyryl-2′-O-(2-methoxyethyl)guanosine

A revised, optimized process for the manufacture of 5′-O-(4,4′-dimethoxytrityl)-N2-isobutyryl-2′-O-(2- methoxyethyl)guanosine (MOE G PNS) that controls critical impurities to less than 0.2% was developed. The 2′-O-alkylation of 2,6-diaminopurine riboside

Process development for the synthesis of 5′-O-(4,4′ -dimethoxytrityl)-N2-isobutyryl-2′-O-(2-methoxyethyl) -guanosine - A potential precursor for the second generation antisense oligonucleotides: An improved process for the preparation of 2′-O-a

An efficient four step process for the preparation of 5′ -O-(4,4′-dimethoxytrityl)-N2-isobutyryl-2′-O-(2-methoxyethyl) -guanosine 1 was developed. Direct 2′-O-alkylation of 2,6-diaminopurine riboside 2 was accomplished via inexpensive and commercially ava

Synthesis and cellular activity of stereochemically-pure 2′-O-(2-methoxyethyl)-phosphorothioate oligonucleotides

Stereochemically-pure 2′-O-(2-methoxyethyl)-phosphorothioate (PS-MOE) oligonucleotides were synthesized from new chiral oxazaphospholidine-containing nucleosides. Thermal stability studies showed that the incorporation of Rp-PS linkages increased RNA-binding affinity. In cells, a full Rp-PS-MOE splice-switching oligonucleotide targeting part of the ferrochelatase gene was more potent than its Sp-PS counterpart, but of similar potency to the stereorandom PS-parent sequence.