25173-09-5

Basic information

• Product Name: 2-phenyl-N,N-dipropylacetamide
• CAS NO: 25173-09-5
• Molecular Formula: C₁₄H₂₁NO
• Molecular Weight: 219.3226
• Mol File: 25173-09-5.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 339.2°C at 760 mmHg
• Flash Point: 146.9°C
• Density: 0.971g/cm³
• Vapor Pressure: 9.32E-05mmHg at 25°C
• Refractive Index: 1.508
• CAS DataBase Reference: 2-phenyl-N,N-dipropylacetamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-phenyl-N,N-dipropylacetamide(25173-09-5)
• EPA Substance Registry System: 2-phenyl-N,N-dipropylacetamide(25173-09-5)

Safety Data

• Hazardous Substances Data: 25173-09-5(Hazardous Substances Data)

Upstream product

• 142-84-7 di-n-propylamine 
• 103-80-0 phenylacetyl chloride 
• 103-82-2 phenylacetic acid 
• 932-87-6 1-Bromo-2-phenylacetylene 
• 60-12-8 2-phenylethanol 
• 201230-82-2 carbon monoxide 
• 20441-12-7 N-benzyl-N,N-dipropylamine 

Downstream Products

• 23916-02-1 N-2-(phenylethyl)-N,N-dipropyl-amine 

Relevant articles and documents

Efficient and accessible silane-mediated direct amide coupling of carboxylic acids and amines

A straightforward method for the direct synthesis of amides from amines and carboxylic acids without exclusion of air or moisture using diphenylsilane with N-methylpyrrolidine has been developed. Various amides are made efficiently, and broad functional group compatibility is shown through a Glorius robustness study. A gram-scale synthesis demonstrates the scalability of this method. This journal is

Direct amidation of carboxylic acids with tertiary amines: Amide formation over copper catalysts through C-N bond cleavage

A copper-catalyzed system for the amidation of carboxylic acids with tert-amines through C-N bond cleavage was developed. This protocol is practical and represents a simple way to produce functionalized amides from basic starting materials in moderate to good yields. A plausible mechanism is proposed for the reaction. Copyright

Practical synthesis of amides from alkynyl bromides, amines, and water

A general and efficient method for the synthesis of a wide range of amides is described here. The reactions were conducted under convenient conditions and provided secondary and tertiary amides in moderate to excellent yields. A variety of amines and substituted alkynyl bromides were used to investigate the scope of the reactions.