2519-89-3

Basic information

• Product Name: methyl (R)-4,5-dihydro-2-methylthiazole-4-carboxylate
• Synonyms: methyl (R)-4,5-dihydro-2-methylthiazole-4-carboxylate;(4R)-2-Methyl-2-thiazoline-4α-carboxylic acid methyl ester;(4R)-4,5-Dihydro-2-methyl-4-thiazolecarboxylic acid methyl ester;Einecs 219-747-0
• CAS NO: 2519-89-3
• Molecular Formula: C₆H₉NO₂S
• Molecular Weight: 159.20616
• EINECS: 219-747-0
• Mol File: 2519-89-3.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 216.6°C at 760 mmHg
• Flash Point: 84.8°C
• Appearance: /
• Density: 1.3g/cm³
• Vapor Pressure: 0.139mmHg at 25°C
• Refractive Index: 1.577
• CAS DataBase Reference: methyl (R)-4,5-dihydro-2-methylthiazole-4-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl (R)-4,5-dihydro-2-methylthiazole-4-carboxylate(2519-89-3)
• EPA Substance Registry System: methyl (R)-4,5-dihydro-2-methylthiazole-4-carboxylate(2519-89-3)

Safety Data

• Hazardous Substances Data: 2519-89-3(Hazardous Substances Data)

Usage

InChI:InChI=1/C6H9NO2S/c1-4-7-5(3-10-4)6(8)9-2/h5H,3H2,1-2H3

Upstream product

• 2485-62-3 L-Cysteine methyl ester 
• 1000-84-6 O-ethyl acetimidate 
• 2208-07-3 ethyl acetimidate hydrochloride 
• 5714-80-7 cysteine methyl ester hydrochloride 
• 116077-24-8 S-<2-Chlor-2-(methoxycarbonyl)ethyl>thioacetamid-hydrochlorid 
• 75-36-5 acetyl chloride 
• 18598-63-5 L-cysteine methyl ester hydrochloride 
• 1084772-05-3 C₆H₁₁NO₃S 
• 1393377-75-7 dimethyl (2R,2'R)-3,3'-disulfanediylbis(2-azidopropanoate) 
• 64-19-7 acetic acid 
• 190601-71-9 2-methyl-4,5-dihydrothiazole-4-carboxylic acid 
• 74-88-4 methyl iodide 

Downstream Products

• 6436-60-8 methyl 2-methyl-1,3-thiazole-4-carboxylate 
• 52-89-1 l-cysteine hydrochloride 

Relevant articles and documents

Method for preparing 2,4-disubstituted thiazoline compound from acyl chloride

The invention provides a novel method for preparing 2,4-disubstituted thiazoline at high yield by firstly reacting acyl chloride serving as a raw material and beta-azide disulfide and also provides a general formula I and application of a product, namely a 2,4-disubstituted thiazoline compound. By using the method, the defects of synthesis complexity, high byproduct yield and slightly low yield of the existing method are overcome, and the method has the advantages of high yield (up to 90% or above), high repeatability and suitability for preparation on a relatively large scale.

Concise synthesis of 2,4-disubstituted thiazoles from β-azido disulfides and carboxylic acids or anhydrides: Asymmetric synthesis of cystothiazole C

A novel and efficient method for the one-pot synthesis of 2,4-disubstituted thiazoles from carboxylic acids or anhydrides is presented. Based on this new method, the total synthesis of the bis-2,4-disubstituted bis(thiazoles) natural product cystothiazole C is also presented. This journal is

Copper-catalyzed oxidation of azolines to azoles

We report herein convenient, aerobic conditions for the oxidation of thiazolines to thiazoles and data regarding the oxidation mechanism. These reactions feature operationally simple and environmentally benign conditions and proceed in good yield to afford the corresponding azoles, thus enabling the inexpensive preparation of valuable molecular building blocks. Incorporation of a novel diimine-ligated copper catalyst, [(MesDABMe) CuII(OH2)3]2+ [-OTf] 2, provides increased reaction efficiency in many cases. In other cases copper-free conditions involving a stoichiometric quantity of base affords superior results.