2519-93-9

Basic information

• Product Name: 2-(4-methoxyphenyl)-4,5-dihydro-1,3-thiazole
• Synonyms: 2-(4-methoxyphenyl)-4,5-dihydro-1,3-thiazole
• CAS NO: 2519-93-9
• Molecular Formula: C₁₀H₁₁NOS
• Molecular Weight: 193.26544
• Mol File: 2519-93-9.mol
• Article Data: 17

Chemical Properties

• Boiling Point: 321°C at 760 mmHg
• Flash Point: 147.9°C
• Appearance: /
• Density: 1.19g/cm³
• Vapor Pressure: 0.000576mmHg at 25°C
• Refractive Index: 1.605
• CAS DataBase Reference: 2-(4-methoxyphenyl)-4,5-dihydro-1,3-thiazole(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-methoxyphenyl)-4,5-dihydro-1,3-thiazole(2519-93-9)
• EPA Substance Registry System: 2-(4-methoxyphenyl)-4,5-dihydro-1,3-thiazole(2519-93-9)

Safety Data

• Hazardous Substances Data: 2519-93-9(Hazardous Substances Data)

Usage

InChI:InChI=1/C10H11NOS/c1-12-9-4-2-8(3-5-9)10-11-6-7-13-10/h2-5H,6-7H2,1H3

Upstream product

• 13084-25-8 1-(4-methoxy-thiobenzoyl)-aziridine 
• 156-57-0 2-mercaptoethylamine hydrochloride 
• 95064-52-1 methyl 4-methoxybenzimidate 
• 57774-72-8 ethyl p-methoxy-phenyl-carbothionylcarbamate 
• 57728-69-5 N-(2-hydroxyethyl)-p-methoxybenzamide 
• 96316-04-0 N-(2-hydroxyethyl)-4-methoxybenzothioamide 
• 874-90-8 4-methoxybenzonitrile 
• 60-23-1 Cysteamine 
• 4231-69-0 1-(4-methoxybenzoyl)-1H-1,2,3-benzotriazole 
• 3672-47-7 3-oxo-3-(4'-methoxyphenyl)propanenitrile 
• 100-09-4 4-methoxybenzoic acid 
• 123-11-5 4-methoxy-benzaldehyde 
• 100-07-2 4-methoxy-benzoyl chloride 
• 141-43-5 ethanolamine 

Downstream Products

• 94615-66-4 (5R,6S)-5-(4-Methoxy-phenyl)-6-phenoxy-4-thia-1-aza-bicyclo[3.2.0]heptan-7-one 
• 96160-03-1 2-(4-Methoxy-phenyl)-3-methyl-4,5-dihydro-thiazol-3-ium; iodide 

Relevant articles and documents

Visible Light-Promoted Aryl Azoline Formation over Mesoporous Organosilica as Heterogeneous Photocatalyst

N-heterocyclic compounds demonstrate wide applications ranging from natural compound production to coordination chemistry. Usually, the synthesis of N-heterocyclic compounds is conducted under thermal conditions, mostly by Lewis acids or metal-containing compounds as molecular catalysts. Here, we report a photocatalytic route for aryl azoline formation by mesoporous organosilica as visible light-active and heterogeneous photocatalyst. Via formation of aromatic aldehydes with various amines, 2-phenyl-2-imidazoline, 2-phenyl-2-oxazoline, 2-phenyl-2-thiazoline and their derivatives could be formed with high conversion and selectivity. Additionally, the organosilica photocatalyst showed high stability and reusability.

A single-reagent-driven multistep one-pot preparation of thiazolines and 1,3-thiazines from aldoximes, nitriles, and carboxylic acids

N-(ω-Bromoalkyl)dichlorothiophosphoramidates have been designed as a new class of reagent for the single-reagent-driven multistep preparation of 2-substituted thiazolines and 1,3-thiazines from ald-oximes, nitriles, or carboxylic acids. A wide range of substrates both aromatic as well as aliphatic were investigated and found suitable for the developed protocol.

Selective thioacylation of amines in water: A convenient preparation of secondary thioamides and thiazolines

Primary thioamides have been utilised directly in water, without any derivatisation, to selectively thioacylate primary amines. By employing 2-hydroxyethylamines, the reaction can be extended to the preparation of 2-thiazolines via formation of β-hydroxythioamides.