251922-46-0

Basic information

• Product Name: 3-Oxetaneethanol
• Synonyms: 3-Oxetaneethanol;2-(oxetan-3-yl)ethanol;2-(oxetan-3-yl)ethano;2-(oxetan-3-yl)ethan-1-ol
• CAS NO: 251922-46-0
• Molecular Formula: C₅H₁₀O₂
• Molecular Weight: 102.1317
• Mol File: 251922-46-0.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 206℃
• Flash Point: 96℃
• Appearance: /
• Density: 1.051
• Storage Temp.: 2-8°C
• PKA: 14.95±0.10(Predicted)
• CAS DataBase Reference: 3-Oxetaneethanol(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Oxetaneethanol(251922-46-0)
• EPA Substance Registry System: 3-Oxetaneethanol(251922-46-0)

Safety Data

• RIDADR: UN1993
• Hazardous Substances Data: 251922-46-0(Hazardous Substances Data)

Usage

General Description

3-Oxetaneethanol, also known as 3-oxetanol, is a colorless liquid compound with a molecular formula C4H8O2. It is a cyclic ether alcohol that is used as a solvent and chemical intermediate in various industrial processes. It is a flammable and potentially hazardous compound that should be handled with care. 3-Oxetaneethanol has been used in the manufacture of pharmaceuticals, and also as a solvent and a component in perfumes and flavorings. It is also known for its ability to mediate in the synthesis of various organic compounds and is considered a valuable building block in organic chemistry.

Upstream product

• 569678-81-5 3-(2-(benzyloxy)ethyl)oxetane 
• 41478-45-9 Diethyl<(2-benzyloxy)ethyl>malonate 
• 77661-80-4 2-(2-(benzyloxy)ethyl)propane-1,3-diol 
• 569678-80-4 toluene-4-sulfonic acid 4-benzyloxy-2-hydroxymethyl-butyl ester 
• 1310381-54-4 2-(oxetan-3-yl) acetic acid 

Downstream Products

• 124391-75-9 -(+)-3-hydroxymethyltetrahydrofuran 
• 1135039-66-5 2-(oxetan-3-yl)ethyl 4-methylbenzenesulfonate 

Relevant articles and documents

Nonclassical Phenyl Bioisosteres as Effective Replacements in a Series of Novel Open-Source Antimalarials

The replacement of one chemical motif with another that is broadly similar is a common method in medicinal chemistry to modulate the physical and biological properties of a molecule (i.e., bioisosterism). In recent years, bioisosteres such as cubane and bicyclo[1.1.1]pentane (BCP) have been used as highly effective phenyl mimics. Herein, we show the successful incorporation of a range of phenyl bioisosteres during the open-source optimization of an antimalarial series. Cubane (19) and closo-carborane (23) analogues exhibited improved in vitro potency against Plasmodium falciparum compared to the parent phenyl compound; however, these changes resulted in a reduction in metabolic stability; unusually, enzyme-mediated oxidation was found to take place on the cubane core. A BCP analogue (22) was found to be equipotent to its parent phenyl compound and showed significantly improved metabolic properties. While these results demonstrate the utility of these atypical bioisosteres when used in a medicinal chemistry program, the search to find a suitable bioisostere may well require the preparation of many candidates, in our case, 32 compounds.

PIPERIDINE-DIONE DERIVATIVES

The invention provides novel compounds having the general formula (I) and tautomers and pharmaceutically acceptable salts thereof, wherein A1, A2, A3, A4, R1, R4, R5, R6, R7 and R8 are as defined herein, compositions including the compounds and methods of using the compounds.

Enantioselective intramolecular openings of oxetanes catalyzed by (salen)Co(lll) complexes: Access to enantioenriched tetrahydrofurans

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