251996-49-3

Basic information

• Product Name: Carbamic acid, [4-[(5-chloro-4-formyl-3-pyridinyl)oxy]phenyl]-, 1,1-dimethylethyl ester
• CAS NO: 251996-49-3
• Molecular Formula: C17H17ClN2O4
• Molecular Weight: 348.786
• Mol File: 251996-49-3.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: Carbamic acid, [4-[(5-chloro-4-formyl-3-pyridinyl)oxy]phenyl]-, 1,1-dimethylethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Carbamic acid, [4-[(5-chloro-4-formyl-3-pyridinyl)oxy]phenyl]-, 1,1-dimethylethyl ester(251996-49-3)
• EPA Substance Registry System: Carbamic acid, [4-[(5-chloro-4-formyl-3-pyridinyl)oxy]phenyl]-, 1,1-dimethylethyl ester(251996-49-3)

Safety Data

• Hazardous Substances Data: 251996-49-3(Hazardous Substances Data)

Upstream product

• 54840-15-2 4-N-tert-butoxycarbonylaminophenol 
• 136590-83-5 3,5-dichloropyridine-4-carboxaldehyde 

Downstream Products

• 251996-51-7 4-{4-[(tert-butyloxycarbonyl)amino]phenoxy}thieno[2,3-c]pyridine-2-carboxamide 
• 251993-33-6 4-[4-iodophenoxy]thieno[2,3-c]pyridine-2-carboxamide 
• 251994-31-7 4-(4-aminophenoxy)thieno[2,3-c]pyridine-2-carboxamide 
• 251996-50-6 methyl 4-(4-tert-butoxycarbonylaminophenoxy)thieno[2,3-c]pyridine-2-carboxylate 

Relevant articles and documents

Synthesis and mode of action of 125I- and 3H-labeled thieno[2,3-c]pyridine antagonists of cell adhesion molecule expression

A series of thieno[2,3-c]pyridine antagonists of cell adhesion molecule (CAM) expression, such as A-205804 (1) and A-249377 (2), selectively suppressed the induced expression of E-selectin and ICAM-1 over VCAM-1. In an effort to explore the biological mechanism of action of these inhibitors, we synthesized 125I- and 3H-labeled thieno[2,3-c]pyridines 5 and 6. An isolated diazonium tetrafluoroborate salt efficiently trapped Na125I on very small scale (7.5 μg of Na125I), providing the corresponding 125I-labeled thieno[2,3-c]pyridine in modest yield. Preliminary mechanistic investigations using these radiolabeled compounds revealed that, upon incubation with human umbilical vein endothelial cells (HUVECs), these inhibitors of CAM expression translocated to the cell nucleus and were noncovalently associated with macromolecules of molecular weight greater than 650 kDa.