252002-43-0

Basic information

• Product Name: 4-(2-fluorophenyl)piperidine-4-carbonitrile
• Synonyms: 4-(2-fluorophenyl)piperidine-4-carbonitrile
• CAS NO: 252002-43-0
• Molecular Formula: C₁₂H₁₃FN₂
• Molecular Weight: 204.2434232
• Mol File: 252002-43-0.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-(2-fluorophenyl)piperidine-4-carbonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(2-fluorophenyl)piperidine-4-carbonitrile(252002-43-0)
• EPA Substance Registry System: 4-(2-fluorophenyl)piperidine-4-carbonitrile(252002-43-0)

Safety Data

• Hazardous Substances Data: 252002-43-0(Hazardous Substances Data)

Upstream product

• 726198-18-1 4-cyano-4-(2-fluorophenyl)-1-N-(tert-butyloxycarbonyl)piperidine 
• 326-62-5 2-fluorophenyl acetonitrile 

Downstream Products

• 171-75-5 spiro[indoline-3,4′-piperidine] 
• 252002-44-1 1-N-(3-aminopropyl)-4-cyano-4-(2-fluorophenyl)piperidine 
• 1011484-53-9 cis-4-(2-fluorophenyl)-1-(4-isopropylcyclohexyl)-4-piperidinecarbonitrile 
• 1011484-56-2 cis-1-(tert-butylcyclohexyl)-4-(2-fluorophenyl)-4-piperidinecarbonitrile 

Relevant articles and documents

A convenient synthesis of 1′-H-spiro-(indoline-3,4′-piperidine) and its derivatives

A simple synthetic route has been developed to prepare 1′-H- spiro(indoline-3,4′-piperidine) (1d). Dialkylation of 2- fluorophenylacetonitrile with N-(tert-butyloxycarbonyl)-bis(2-chloroethyl)amine (5) gave 6. Deprotection of Boc followed by cyclization resulted 1d in 67% overall yield. Selective Boc or Cbz protection of 1′-N gave 1a or 1b with 90 and 85% yield, respectively. Thus, in a five-step procedure, 1a and 1b were synthesized from commercially available reagents in over 50% overall yield. All 3 compounds (1a, 1b and 1d) can be utilized as templates to synthesize compounds for GPCR targets.