252049-08-4

Basic information

• Product Name: FMOC-DAB(Z)-OH
• Synonyms: FMOC-ALPHA,GAMMA-DIAMINOBUTYRIC ACID(Z)-OH;FMOC-DAB(Z)-OH;FMOC-L-DIAMINOBUTYRIC BENZYLOXYCARBONYL ACID;FMOC-L-DAB(Z)-OH;FMOC-N-GAMMA-Z-L-2,4-DIAMINOBUTYRIC ACID;N-ALPHA-(9-FLUORENYLMETHYLOXYCARBONYL)-N-GAMMA-(BENZYLOXYCARBONYL)-L-2,4-DIAMINOBUTYRIC ACID;N-ALPHA-(9-FLUORENYLMETHOXYCARBONYL)-N-GAMMA-CARBOBENZOXY-L-ALPHA,GAMMA-DIAMINOBUTYRIC ACID;N-α-Fmoc-N-γ-Z-L-2,4-diaminobutyric acid
• CAS NO: 252049-08-4
• Molecular Formula: C₂₇H₂₆N₂O₆
• Molecular Weight: 474.51
• EINECS: 1533716-785-6
• Product Categories: Unusual Amino Acids;amino acids
• Mol File: 252049-08-4.mol
• Article Data: 2

Chemical Properties

• Melting Point: 118 °C
• Boiling Point: 739.789 °C at 760 mmHg
• Flash Point: 401.21 °C
• Appearance: White/Powder
• Density: 1.299 g/cm³
• Storage Temp.: 2-8°C
• PKA: 3.79±0.10(Predicted)
• Water Solubility: Slightly soluble in water.
• CAS DataBase Reference: FMOC-DAB(Z)-OH(CAS DataBase Reference)
• NIST Chemistry Reference: FMOC-DAB(Z)-OH(252049-08-4)
• EPA Substance Registry System: FMOC-DAB(Z)-OH(252049-08-4)

Safety Data

• Hazardous Substances Data: 252049-08-4(Hazardous Substances Data)

Usage

Description

Fmoc-Dab(Z)-OH, also known as (S)-4-Benzyloxycarbonylamino-2-(Fmoc-amino)butyric acid, is a substituted fluorene compound that is widely utilized in various fields due to its unique chemical properties. It is characterized as a white crystalline powder and plays a significant role in proteomics research, as well as in the agrochemical, pharmaceutical, and dyestuff industries.

Uses

Used in Proteomics Research:
Fmoc-Dab(Z)-OH is used as a reagent for the synthesis of peptides and proteins in proteomics research. Its application is crucial for the study of protein structures, functions, and interactions, which are essential for understanding various biological processes and developing new therapeutic strategies.
Used in the Agrochemical Industry:
Fmoc-Dab(Z)-OH is used as an intermediate in the synthesis of agrochemicals, specifically in the development of new pesticides and herbicides. Its unique chemical properties contribute to the creation of more effective and environmentally friendly products for agricultural applications.
Used in the Pharmaceutical Industry:
Fmoc-Dab(Z)-OH is used as a building block in the synthesis of various pharmaceutical compounds, including drugs for the treatment of different diseases. Its versatility in chemical reactions allows for the development of innovative and potent therapeutic agents.
Used in the Dyestuff Industry:
Fmoc-Dab(Z)-OH is used as a key component in the production of dyes and pigments for various applications, such as textiles, plastics, and printing inks. Its unique chemical structure enables the creation of vibrant and stable colorants that meet the demands of the dyestuff industry.

Upstream product

• 201867-52-9 (S)-(3-fluoren-9-ylmethoxycarbonyl)-4-[2-(benzyloxycarbonylamino)ethyl]-5-oxazolidinone 
• 918428-66-7 9H-9-fluorenylmethyl (4S)-4-(3-azido-2-oxopropyl)-5-oxo-1,3-oxazolone-3-carboxylate 
• 100-51-6 benzyl alcohol 
• 159530-17-3 N^α-Fmoc-Glu-5-oxazolidinone 

Relevant articles and documents

Synthesis method of double different protected amino acids

The invention relates to a synthesis method of double different protected amino acids.The technical problems of harsh reaction conditions, inapplicability of production enlarging and the like in an existing synthesis method are mainly solved. According to the technical scheme, the synthesis method of double different protected amino acids comprises the following steps: one of Boc20, Alloc-Cl or Cbz-Osuis added to amino alcohol under the action of an alkaline reagent to obtain a compound 1; the compound 1 reacts with methanesulfonyl chloride or paratoluensulfonyl chloride to obtain an intermediate, then a halide is added into acetone, heating and refluxing are executed to obtain a compound 2; the compound 2 is condensed with diethyl acetamidomalonate under the action of an alkaline agent togenerate a compound 3; the compound 3 is dissolved in alcohol and water, an inorganic base is added, heating, hydrolyzing and decarboxylating are executed to obtain a compound 4; acetylase is added into deionized water to obtain a compound 5 through enzymolysis; amino acid protection is executed, wherein one of Fmoc-Osu, Cbz-OSu, Alloc-Cl or Boc20 is added into thecompound 5 under the action of an alkaline agent to generatea target compound A.