252049-10-8

Basic information

• Product Name: FMOC-LYS(ME)2-OH HCL
• Synonyms: N-ALPHA-FMOC-N-EPSILON,EPSILON-DIMETHYL-L-LYSINE HYDROCHLORIDE SALT;N-ALPHA-(9-FLUORENYLMETHYLOXYCARBONYL)-N-EPSILON-DIMETHYL-L-LYSINE HYDROCHLORIDE;N-ALPHA-(9-FLUORENYLMETHOXYCARBONYL)-N-EPSILON,N-EPSILON-DIMETHYL-L-LYSINE HYDROCHLORIDE;FMOC-LYS(ME)2-OH HCL;FMOC-LYSINE(ME)2-OH HCL;FMOC-N-EPSILON-DIMETHYL-L-LYSINE HYDROCHLORIDE;FMOC-N-EPSILON,EPSILON-DIMETHYL-L-LYSINE HYDROCHLORIDE SALT;FMOC-L-LYS(ME2)-OH HCL
• CAS NO: 252049-10-8
• Molecular Formula: C23H29ClN2O4
• Molecular Weight: 432.94
• Product Categories: Amino Acids & Derivatives;Fluorescent Labels & Indicators;Intermediates & Fine Chemicals;Pharmaceuticals;proteins;amino acids
• Mol File: 252049-10-8.mol
• Article Data: 0

Chemical Properties

• Appearance: /
• Storage Temp.: -15°C
• Solubility: DMSO (Slightly), Methanol (Slightly)
• CAS DataBase Reference: FMOC-LYS(ME)2-OH HCL(CAS DataBase Reference)
• NIST Chemistry Reference: FMOC-LYS(ME)2-OH HCL(252049-10-8)
• EPA Substance Registry System: FMOC-LYS(ME)2-OH HCL(252049-10-8)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 252049-10-8(Hazardous Substances Data)

Usage

Description

FMOC-LYS(ME)2-OH HCL, also known as Nα-(9-fluorenylmethoxycarbonyl)-Nε,Nε-dimethyl-L-lysine hydrochloride, is a di-methyl L-lysine derivative used in the field of peptide synthesis. It is a white to off-white crystalline powder that plays a crucial role in the post-translational modification of histone tails, which is essential for the regulation of chromatin condensation. This modification involves the binding of methylated lysine in aromatic pockets on chromodomain proteins.

Uses

Used in Peptide Synthesis:
FMOC-LYS(ME)2-OH HCL is used as a building block for the solid-phase peptide synthesis (SPPS) of histone-related peptides containing methylated arginine and lysine residues. The incorporation of this di-methyl L-lysine derivative allows for the creation of peptides with specific post-translational modifications, which are essential for understanding the role of histone methylation in various biological processes.
Used in Epigenetic Research:
FMOC-LYS(ME)2-OH HCL is used as a research tool for studying the role of histone methylation in epigenetic regulation. By incorporating this derivative into synthetic peptides, researchers can investigate the interactions between methylated histones and chromodomain proteins, as well as the effects of these interactions on gene expression and cellular processes.
Used in Drug Discovery:
FMOC-LYS(ME)2-OH HCL is used as a starting material for the development of novel therapeutic agents targeting epigenetic modifications. The ability to synthesize peptides with specific post-translational modifications, such as methylation, can lead to the discovery of new drugs that modulate histone-chromodomain interactions and potentially treat diseases associated with aberrant epigenetic regulation.
Used in Chemical Synthesis:
FMOC-LYS(ME)2-OH HCL is used as a reagent in the synthesis of various chemical compounds, particularly those involving the modification of amino acids or peptides. Its unique structure and properties make it a valuable building block for the development of new molecules with potential applications in various fields, including pharmaceuticals, materials science, and biotechnology.