252049-17-5

Basic information

• Product Name: FMOC-D-GLU-OFM
• Synonyms: FMOC-D-GLUTAMIC ACID ALPHA-9-FLUORENYLMETHYL ESTER;FMOC-D-GLUTAMIC ACID-OFM;FMOC-D-GLU-OFM;N-ALPHA-(9-FLUORENYLMETHOXYCARBONYL)-D-GLUTAMIC ACID ALPHA-FLUORENYLMETHYL ESTER;Fmoc-D-glutamic acid α-9-fluorenylmethyl ester≥ 98%;(9H-Fluoren-9-yl)MethOxy]Carbonyl D-Glu-Ofm
• CAS NO: 252049-17-5
• Molecular Formula: C34H29NO6
• Molecular Weight: 547.6
• Mol File: 252049-17-5.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 795.3±60.0 °C(Predicted)
• Appearance: /
• Density: 1.303±0.06 g/cm3(Predicted)
• Storage Temp.: -15°C
• PKA: 4.44±0.10(Predicted)
• CAS DataBase Reference: FMOC-D-GLU-OFM(CAS DataBase Reference)
• NIST Chemistry Reference: FMOC-D-GLU-OFM(252049-17-5)
• EPA Substance Registry System: FMOC-D-GLU-OFM(252049-17-5)

Safety Data

• Hazardous Substances Data: 252049-17-5(Hazardous Substances Data)

Usage

General Description

FMOC-D-GLU-OFM, also known as Fmoc-D-Glu(OFm)-OH, is a chemical compound used in scientific research, specifically in peptide synthesis. The "Fmoc" in the name stands for 9-fluorenylmethyloxycarbonyl, a type of chemical group that helps protect the amine group during peptide synthesis. The "OFM" stands for O-9-Fluorenylmethyl Ester, which provides protection to the carboxyl group during the synthesis process. It is often employed in the production of complex peptides and proteins, contributing to research in areas such as drug development and understanding biological processes.

Upstream product

• 24324-17-2 9-Fluorenylmethanol 
• 71989-18-9 Fmoc-Glu(OtBu)-OH 

Relevant articles and documents

Synthetic method of cyclic dipeptide containing aspartic acid and glutamic acid

The invention discloses a synthetic method of cyclic dipeptide containing aspartic acid and glutamic acid, which comprises the following steps: by taking Fmoc-Asp (OtBu)-OH or Fmoc-Glu (OtBu)-OH as a raw material, reacting with 9-fluorene methanol to obtain fluorene methyl ester of fully protected amino acid, and then removing side chain tert-butoxy to obtain protected amino acid Fmoc-Asp-OFm or Fmoc-Glu-OFm; 2-CTC Resin resin is used as a carrier to be bonded with Fmoc-Asp-OFm or Fmoc-Glu-OFm side chain gamma-carboxyl, solid-phase cyclization is carried out to synthesize full-protection cyclic dipeptide, and the cyclic dipeptide with aspartic acid or glutamic acid at the carbon end is obtained through cutting and cracking. According to the method, 9-fluorene methanol is introduced to protect carboxyl, the carboxyl can be smoothly removed in the solid-phase synthesis process of the dipeptide, the whole process is easy to operate, the solid-phase cyclization efficiency is high, the purity is high, and the method can be suitable for batch synthesis of cyclic dipeptide with aspartic acid or glutamic acid at the carbon end.