252051-12-0

Basic information

• Product Name: (4R,1'R)-[1-(1'-phenylethyl)-2-oxopyrrolidin-4-yl]carboxaldehyde
• Synonyms: (4R,1'R)-[1-(1'-phenylethyl)-2-oxopyrrolidin-4-yl]carboxaldehyde
• CAS NO: 252051-12-0
• Molecular Weight: 217.268
• Mol File: 252051-12-0.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 393.4±42.0 °C(Predicted)
• Density: 1.217±0.06 g/cm3(Predicted)
• CAS DataBase Reference: (4R,1'R)-[1-(1'-phenylethyl)-2-oxopyrrolidin-4-yl]carboxaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: (4R,1'R)-[1-(1'-phenylethyl)-2-oxopyrrolidin-4-yl]carboxaldehyde(252051-12-0)
• EPA Substance Registry System: (4R,1'R)-[1-(1'-phenylethyl)-2-oxopyrrolidin-4-yl]carboxaldehyde(252051-12-0)

Safety Data

• Hazardous Substances Data: 252051-12-0(Hazardous Substances Data)

Usage

Description

(4R,1'R)-[1-(1'-phenylethyl)-2-oxopyrrolidin-4-yl]carboxaldehyde is a complex organic compound with the molecular formula C16H17NO2. It is a derivative of the natural amino acid proline and is classified as an aldehyde. (4R,1'R)-[1-(1'-phenylethyl)-2-oxopyrrolidin-4-yl]carboxaldehyde is characterized by its unique chiral centers, with the (4R,1'R) configuration, which is crucial for its potential applications in various fields.

Uses

Used in Pharmaceutical Industry:
(4R,1'R)-[1-(1'-phenylethyl)-2-oxopyrrolidin-4-yl]carboxaldehyde is used as a key intermediate in the synthesis of various pharmaceuticals and fine chemicals. Its unique structure and potential pharmacological activity make it a valuable building block in the development of therapeutic agents and other biologically active compounds.
Used in Organic Synthesis:
In the field of organic synthesis, (4R,1'R)-[1-(1'-phenylethyl)-2-oxopyrrolidin-4-yl]carboxaldehyde serves as a versatile starting material for the preparation of complex organic molecules. Its reactivity and structural features allow for the creation of a wide range of chemical entities with diverse applications.
Used in Medicinal Chemistry:
(4R,1'R)-[1-(1'-phenylethyl)-2-oxopyrrolidin-4-yl]carboxaldehyde is utilized in medicinal chemistry as a component in the design and synthesis of new drugs. Its potential pharmacological properties and ability to form stable chiral centers make it an attractive candidate for the development of innovative therapeutic agents.

Upstream product

• 99735-43-0 (3R)-1-((R)-1-phenylethyl)-5-oxo-3-pyrrolidinecarboxylic acid 
• 190957-22-3 (4R,1'R)-1-(1'-phenylethyl)-4-hydroxymethylpyrrolidin-2-one 

Downstream Products

• 252051-15-3 (4S,1'R)-1-(1'-phenylethyl)-4-naphthylaminomethylpyrrolidin-2-one 
• 252051-16-4 (3S,1'S)-1-(1'-phenylethyl)-3-naphthylaminomethylpyrrolidine 
• 252051-14-2 (4R,1'R)-1-(1'-phenylethyl)-4-methanesulfonyloxymethylpyrrolidin-2-one 
• 190957-22-3 (4R,1'R)-1-(1'-phenylethyl)-4-hydroxymethylpyrrolidin-2-one 

Relevant articles and documents

SUBSTITUTED NAPHTHYRIDINES AND THEIR USE AS MEDICAMENTS

The invention relates to new substituted naphthyridines of formula 1, as well as pharmacologically acceptable salts, diastereomers, enantiomers, racemates, hydrates or solvates thereof, wherein R1 is selected from among —O—R3 or —NR3R4,R3 is C1-6-alkyl which is substituted by R5 and R6,R5 is selected from hydrogen, branched or linear C1-6-alkyl, C2-6-alkenyl, —C1-6-alkylen-O—C1-3-alkyl, C1-3-haloalkyl,R6 is ring X wherein n is either 0 or 1, and is a either a single or a double bond andwherein A, B, D and E are each independently from one another selected from CH2, CH, C, N, NH, O or S and wherein ring X is attached to the molecule either via position A, B, D or E, wherein said ring X may optionally be further substituted by one, two or three residues each selected individually from the group consisting of -oxo, hydroxy, —C1-3-alkyl, —C1-3-haloalkyl, —O—C1-3-alkyl, —C1-3-alkanol and halogen,and wherein R4, R2, R7, R8, R9, R10, R11 and Q may have the meanings as given in claim 1, as well as pharmaceutical compositions containing these compounds.

PYRIDOBENZOXAZINE DERIVATIVE

A quinolone antimicrobial agent having potent antimicrobial activity against gram positive and gram negative bacteria and having high safety is provided. A compound represented by the following formula (1): [wherein, R1: hydrogen, alkyl, cycloalkyl, or substituted carbonyl derived from amino acid, peptide or tripeptide; R2: hydrogen, alkyl, or cycloalkyl; R3: hydrogen, amino, halogen, or alkyl; R4: hydrogen, phenyl, acetoxymethyl, pivaloyloxymethyl, ethoxycarbonyl, choline, dimethylaminoethyl, 5-indanyl, phthalidinyl, 5-alkyl-2-oxo-1,3-dioxol-4-ylmethyl, 3-acetoxy-2-oxobutyl, alkyl, alkoxymethyl, or phenylalkyl; X, X1, X2: hydrogen or halogen] or salt thereof, or a hydrate thereof; and antimicrobial agent and therapeutic agent for infections, each containing the compound, salt thereof or a hydrate thereof.