252056-75-0

Basic information

• Product Name: 5-bromo-3-[2-(3,5-dimethyl-phenyl)-ethyl]-pyridine-2-carbonitrile
• CAS NO: 252056-75-0
• Molecular Weight: 315.212
• Mol File: 252056-75-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 5-bromo-3-[2-(3,5-dimethyl-phenyl)-ethyl]-pyridine-2-carbonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 5-bromo-3-[2-(3,5-dimethyl-phenyl)-ethyl]-pyridine-2-carbonitrile(252056-75-0)
• EPA Substance Registry System: 5-bromo-3-[2-(3,5-dimethyl-phenyl)-ethyl]-pyridine-2-carbonitrile(252056-75-0)

Safety Data

• Hazardous Substances Data: 252056-75-0(Hazardous Substances Data)

Upstream product

• 252056-70-5 5-amino-3-methylpyridine-2-carbonitrile 
• 156072-86-5 5-bromo-3-methylpyridine-2-carbonitrile 
• 156072-91-2 5-bromo-N-(tert-butyl)-3-methylpicolinamide 
• 65169-63-3 3-methyl-5-nitropyridine-2-carbonitrile 
• 20970-75-6 2-cyano-3-methylpyridine 

Relevant articles and documents

Analogues of 1-(3,10-Dibromo-8-chloro-6,11-dihydro-5H-benzo[5,6]-cyclohepta[1, 2-b]pyridin-11-yl)piperidine as inhibitors of farnesyl protein transferase

The synthesis of several 4-pyridylacetyl N-oxide derivatives of 4-(3-bromo-6,11-dihydro-5H-benzo[5,6]-cyclohepta[1,2-b]pyridin-11 -yl)piperazine/piperidine 3 is described. This study was aimed at identifying fomesyl protein transferase (FPT) inhibitors in these two series of tricycles containing different phenyl ring substituents. The in vitro activity profile of the initial group of compounds 7a-7g led to the synthesis of the 8-methyl-10-methoxy and 8-methyl-10-bromo analogues 7i, 13i, and 13j. The 11R(-) enantiomers of these compounds were found to exhibit potent in vitro FPT inhibition activity.