2521-89-3

Basic information

• Product Name: glycine, N-(4-chlorophenyl)-, ethyl ester
• Synonyms: ethyl N-(4-chlorophenyl)glycinate;glycine, N-(4-chlorophenyl)-, ethyl ester
• CAS NO: 2521-89-3
• Molecular Formula: C₁₀H₁₂ClNO₂
• Molecular Weight: 213.66078
• Mol File: 2521-89-3.mol
• Article Data: 57

Chemical Properties

• Boiling Point: 321.8°Cat760mmHg
• Flash Point: 148.4°C
• Appearance: /
• Density: 1.229g/cm³
• Vapor Pressure: 0.000291mmHg at 25°C
• Refractive Index: 1.562
• CAS DataBase Reference: glycine, N-(4-chlorophenyl)-, ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: glycine, N-(4-chlorophenyl)-, ethyl ester(2521-89-3)
• EPA Substance Registry System: glycine, N-(4-chlorophenyl)-, ethyl ester(2521-89-3)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 2521-89-3(Hazardous Substances Data)

Usage

General Description

Glycine, N-(4-chlorophenyl)-, ethyl ester is a chemical compound that belongs to the class of esters and is typically used in pharmaceutical research. It is derived from the amino acid glycine, and has an ethyl ester functional group attached to the nitrogen atom of a 4-chlorophenyl group. glycine, N-(4-chlorophenyl)-, ethyl ester has various potential applications in medicinal chemistry, such as in the synthesis of organic molecules and in the development of new drugs. It is also used in research and development for its potential pharmacological properties, including its ability to interact with biological targets in the body. Additionally, it may have other industrial uses and applications in the field of organic chemistry.

InChI:InChI=1/C10H12ClNO2/c1-2-14-10(13)7-12-9-5-3-8(11)4-6-9/h3-6,12H,2,7H2,1H3

Upstream product

• 106-47-8 4-chloro-aniline 
• 105-39-5 chloroacetic acid ethyl ester 
• 64-17-5 ethanol 
• 5465-90-7 N-(4-chlorophenyl)glycine 
• 623-73-4 diazoacetic acid ethyl ester 
• 924-44-7 glyoxylic acid ethyl ester 
• 105-36-2 ethyl bromoacetate 
• 623-48-3 ethyl iodoacetae 
• 109-92-2 ethyl vinyl ether 

Downstream Products

• 2371-31-5 2-((4-chlorophenyl)amino)acetohydrazide 
• 99420-98-1 N-Acetyl-N-(4-chlorophenyl)glycine 
• 5336-36-7 N-[N-acetyl-N-(4-chloro-phenyl)-glycyl]-N-(4-chloro-phenyl)-glycine 
• 55240-02-3 C₁₁H₁₁Cl₂NO₃ 
• 6738-76-7 N-<(4-Chlor-anilino)-acetyl>-N'.N'-dimethyl-ethylendiamin 
• 13334-97-9 N-(p-Chlorphenyl)-α-chlor-acetamidoessigsaeureethylester 
• 92849-14-4 (4-Chlor-anilino)-essigsaeure-(2-dimethylamino-ethylester) 
• 118505-65-0 1-Amino-4-(4-chloro-phenyl)-piperazine-2,5-dione 
• 92516-00-2 C₁₅H₁₅ClN₄OS 
• 142503-67-1 3-(4-chloroanilinomethyl)-4-amino-5-mercapto-1,2,4-triazole 

Relevant articles and documents

Perovskite as Recyclable Photocatalyst for Annulation Reaction of N-Sulfonyl Ketimines

A sustainable and cost-effective manner for the photocatalytic annulation reaction of N-sulfonyl ketimines with N-arylglycines to synthesize imidazolidine-fused sulfamidates (31 examples) by employing CsPbBr3 as a heterogeneous photocatalyst has been developed. The catalyst CsPbBr3 can be simply recovered from the reaction mixture and reused at least five times without an obvious reduction in its photocatalytic reactivity, exhibiting a high catalyst economic feature.

Selective carbene transfer to amines and olefins catalyzed by ruthenium phthalocyanine complexes with donor substituents

Electron-rich ruthenium phthalocyanine complexes were evaluated in carbene transfer reactions from ethyl diazoacetate (EDA) to aromatic and aliphatic olefins as well as to a wide range of aromatic, heterocyclic and aliphatic amines for the first time. It was revealed that the ruthenium octabutoxyphthalocyanine carbonyl complex [(BuO)8Pc]Ru(CO) is the most efficient catalyst converting electron-rich and electron-poor aromatic olefins to cyclopropane derivatives with high yields (typically 80-100%) and high TON (up to 1000) under low catalyst loading and nearly equimolar substrate/EDA ratio. This catalyst shows a rare efficiency in the carbene insertion into amine N-H bonds. Using a 0.05 mol% catalyst loading, a high amine concentration (1 M) and 1.1 eq. of EDA, a number of structurally divergent amines were selectively converted to mono-substituted glycine derivatives with up to quantitative yields and turnover numbers reaching 2000. High selectivity, large substrate scope, low catalyst loading and practical reaction conditions place [(BuO)8Pc]Ru(CO) among the most efficient catalysts for the carbene insertion into amines.

Photoredox-Catalyzed α-Aminomethyl Carboxylation of Styrenes with Sodium Glycinates: Synthesis of γ-Amino Acids and γ-Lactams

A visible-light photoredox-catalyzed reductive α-aminomethyl carboxylation of styrenes with sodium glycinates and CO2 has been developed to synthesize a series of α,α-disubstituted γ-amino acids and γ-lactams with high efficiency and regioselectivity. Notably, CO2 released from the decarboxylation step can be reused for the subsequent carboxylation. Distinct from the previous reactions with the same type of substrates leading to simple decarboxylation and olefin hydroalkylation, this process involves additional CO2 sequestration, thus leading to olefin α-aminomethyl carboxylation. These findings not only provide new access to α,α-disubstituted γ-amino acids and γ-lactams but also serve as a proof of concept for CO2 reutilization in decarboxylation reactions.