25245-37-8Relevant articles and documents
Potent hemithioindigo-based antimitotics photocontrol the microtubule cytoskeleton in cellulo
Ahlfeld, Julia,Bingham, Rebekkah,Ermer, Franziska,Kraus, Yvonne,Lutter, Ferdinand H.,Sailer, Alexander,Thorn-Seshold, Oliver
, p. 125 - 134 (2020)
Background: Hemithioindigo is a promising molecular photoswitch that has only recently been applied as a photoswitchable pharmacophore for control over bioactivity in cellulo. Uniquely, in contrast to other photoswitches that have been applied to biology,
Selective Claisen rearrangement and iodination for the synthesis of polyoxygenated allyl phenol derivatives
Bochicchio, Antonella,Cefola, Rossella,Choppin, Sabine,Colobert, Fran?oise,Di Noia, Maria Antonietta,Funicello, Maria,Hanquet, Gilles,Pisano, Isabella,Todisco, Simona,Chiummiento, Lucia
supporting information, p. 4053 - 4055 (2016/08/18)
Allyl aryl ethers and allyl phenol derivatives were prepared starting from commercial or synthetized phenols. Either Williamson reaction or Et2AlCl catalyzed Claisen rearrangement was performed to obtain the polyoxygenated molecules. The pivotal allyl phenols were then modified by methylation, iodocyclization or electrophilic aromatic iodination to afford the polyoxygenated derivatives in good to excellent yields. Additionally, their antibacterial properties were also investigated against Gram-positive and Gram-negative bacteria.
Nitrogen dioxide-catalyzed electrophilic iodination of arenes
Ren, Yun-Lai,Shang, Huantao,Wang, Jianji,Tian, Xinzhe,Zhao, Shuang,Wang, Qian,Li, Fuwei
supporting information, p. 3437 - 3442 (2013/12/04)
Nitrogen dioxide is demonstrated to be an effective catalyst precursor for the iodination of alkoxy-substituted benzenes and naphthalenes. Different from the transition metal catalysts, nitrogen dioxide can be easily separated from the final products, and is free of heavy metal waste. Although the present catalyst precursor is toxic, it does not stain the final products due to its low-boiling character. No other reagents apart from 0.5 equiv. of iodine (I 2), 6.5 mol% nitrogen dioxide and acetonitrile solvent were used in the iodination, and basically all the iodine atoms in the iodine source were transferred to the iodination products, showing that the presented protocol is highly atom-economic and practical. Copyright