25245-91-4

Basic information

• Product Name: decursin
• CAS NO: 25245-91-4
• Molecular Weight: 328.365
• Mol File: 25245-91-4.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: decursin(CAS DataBase Reference)
• NIST Chemistry Reference: decursin(25245-91-4)
• EPA Substance Registry System: decursin(25245-91-4)

Safety Data

• Hazardous Substances Data: 25245-91-4(Hazardous Substances Data)

Upstream product

• 3350-78-5 3,3-Dimethylacryloyl chloride 
• 5993-18-0 decursinol 
• 108-46-3 recorcinol 
• 354576-62-8 acetic acid 2,2-dimethyl-1a,7b-dihydro-2H-1,3-dioxa-cyclopropa[a]naphthalen-5-yl ester 
• 94527-05-6 4,7-dihydroxy-2,2-dimethylchroman 
• 19012-98-7 7-acetoxy-2,2-dimethyl-2H-chromene 
• 19012-97-6 2,2-dimethyl-7-hydroxy-2H-1-benzopyran 
• 541-47-9 3-Methylbutenoic acid 
• 17771-33-4 7-hydroxy-2,2-dimethyl-chroman-4-one 
• 325138-00-9 6-[(2S)-3-hydroxy-3-methyl-2-(triethylsilyloxy)butyl]-7-(trifluoromethanesulfonyl)chromen-2-one 
• 325137-98-2 6-[(2S)-2,3-dihydroxy-3-methylbutyl]-7-(trifluoromethanesulfonyl)chromen-2-one 
• 616241-75-9 (S)-7,8-dihydro-8,8-dimethyl-7-triethylsilyloxy-6H-pyrano[3,2-g]chromen-2-one 
• 616241-73-7 6-[(2S)-2,3-dihydroxy-3-methylbutyl]-7-(methoxymethoxy)chromen-2-one 
• 325137-96-0 6-[(1R,2S)-1,2-epoxy-3-hydroxy-3-methylbutyl]-7-(methoxymethoxy)chromen-2-one 

Downstream Products

• 5993-18-0 decursinol 
• 5993-18-0 decursinol 
• 51019-80-8 (-)-cis-decursidinol 

Relevant articles and documents

Enantioselective total syntheses of novel PKC activator (+)-decursin and its derivatives using catalytic asymmetric epoxidation of an enone

The catalytic asymmetric total syntheses of (+)-decursin and three related natural products, (+)-decursinol, (-)-prantschimgin and (+)-marmesin, were achieved for the first time using catalytic asymmetric epoxidation of an enone as the key step. The catalytic asymmetric epoxidation of enone was found to be promoted effectively by novel multifunctional asymmetric catalyst generated from La(O-i-Pr)3, BINOL and O=AsPh3 in a 1:1:1 ratio to afford epoxide in 94% yield and 96% ee, which was recrystallized to give the optically pure epoxide. (C) 2000 Elsevier Science Ltd.

Structure-activity relationships for naturally occurring coumarins as β-secretase inhibitor

The present study was demonstrated to evaluate the effects of naturally occurring coumarins (NOCs) including simple coumarins, furanocoumarins, and pyranocoumarins on the inhibition of β-secretase (BACE1) activity. Of 41 NOCs examined, some furanocoumarins inhibited BACE1 activity, but simple coumarins and pyranocoumarins did not affect. The most potent inhibitor was 5-geranyloxy-8-methoxypsoralen (31), which has an IC50 value of 9.9 μM. Other furanocoumarin derivatives, for example, 8-geranyloxy-5- methoxypsoralen (35), 8-geranyloxypsoralen (24), and bergamottin (18) inhibited BACE1 activity, with the IC50 values 25.0 μM. Analyses of the inhibition mechanism by Dixon plots and Cornish-Bowden plots showed that compounds 18, 31 and 35 were mixed-type inhibitor. The kinetics of inhibition of BACE1 by coumarins 24 was non-competitive inhibitors.

NOVEL DECURSIN DERIVATIVES AND THE USE THEREOF

The present invention relates to novel (+)-decursin derivatives having anti-cancer activity, the preparation thereof and a composition containing the same for treating cancer disease. The (+)-decursin derivatives of the present invention showed potent inh