252573-87-8

Basic information

• Product Name: Z-Val-D-Phe-OMe
• Synonyms: Z-Val-D-Phe-OMe
• CAS NO: 252573-87-8
• Molecular Weight: 412.486
• Mol File: 252573-87-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Z-Val-D-Phe-OMe(CAS DataBase Reference)
• NIST Chemistry Reference: Z-Val-D-Phe-OMe(252573-87-8)
• EPA Substance Registry System: Z-Val-D-Phe-OMe(252573-87-8)

Safety Data

• Hazardous Substances Data: 252573-87-8(Hazardous Substances Data)

Upstream product

• 96452-48-1 benzyl pyridin-2-yl carbonate 
• 501-53-1 benzyl chloroformate 
• 7524-50-7 methyl (2S)-2-amino-3-phenylpropanoate hydrochloride 
• 69472-89-5 N-(Benzyloxycarbonyl)-L-valin-2-pyridylester 
• 1149-26-4 (S)-N-(benzyloxycarbonyl)valine 

Downstream Products

• 145313-30-0 (R)-2-((S)-2-Amino-3-methyl-butyrylamino)-3-phenyl-propionic acid methyl ester 
• 35590-87-5 (3S,6R)-3-(1-methylethyl)-6-(phenylmethyl)piperazine-2,5-dione 

Relevant articles and documents

2(1H)-Pyridone as Leaving Group in Acylation Reactions - Applications in Peptide Synthesis

Alkyl 2-pyridyl carbonates 3 or mixtures of 3 and the isomeric N-(alkoxycarbonyl)-2-pyridones 3' are useful for the introduction of urethane protective groups into amino acids.The N-protected amino acids 7 - 10 react with 2(1H)-pyridone (1a) using the carbodiimide method to yield 2-pyridyl active esters 11, which easily undergo coupling reactions with amino acid esters 12 with elimination of 1a to give peptides 13 in good yields as well as high optical purities.