25277-68-3Relevant articles and documents
Preliminary biological assay on cerebroside mixture from Euphorbia nicaeensis All. Isolation and structure determination of five glucocerebrosides
Cateni,Zilic,Falsone,Hollan,Frausin,Scarcia
, p. 809 - 817 (2007/10/03)
Preliminary studies of in vitro cytostatic activity on less polar fraction of the MeOH extract of the plant Euphorbia nicaeensis All., carried out on KB cells, have evinced a relatively low ability of extract to inhibit cell growth. Successive, five glucocerebrosides were isolated from the cerebroside molecular species obtained from this extract using normal and reversed phase column 'flash-chromatography'. The structures of these cerebrosides were determined on the basis of chemical and spectroscopic evidences. Mass spectrometry of dimethyl disulfide derivatives was useful for the determination of the double-bond positions in the long-chain bases.
The principles of Tetragonia tetragonoides having anti-ulcerogenic activity. II. Isolation and structure of cerebrosides
Okuyama,Yamazaki
, p. 2209 - 2219 (2007/10/02)
Compound B1 (tentative name), isolated from Tetrogonia tetragonoides as a principle with anti-ulcerogenic activity, was determined to be a mixture of geometrical isomers of 1-O-β-D-glucopyranosyl-2-N-2'-hydroxypalmitoyl-sphinga-4,8-dienine on the basis of chemical and spectral evidence. By repeated chromatography, compound B1 was separated into compounds B(1-a) (major) and B(1-b) (minor), which were found to be the 4-trans-8-trans and 4-trans-8-cis isomers, respectively. Several cerebrosides and glycolipids from various biological sources were examined for protective activity against the ulcer formation in mice under restraint and water immersion condition.
