25287-79-0

Basic information

• Product Name: 3-(dimethylamino)-1,2-diphenylpropan-1-one hydrochloride (1:1)
• Synonyms: .beta.-Dimethylamino-.alpha.-phenylpropiophenone hydrochloride; 1-Propanone, 3- (dimethylamino)-1,2-diphenyl-, hydrochloride; 1-Propanone, 3-(dimethylamino)-1,2-diphenyl-, hydrochloride (9CI)
• CAS NO: 25287-79-0
• Molecular Formula: C₁₇H₁₉NO*ClH
• Molecular Weight: 289.7998
• Mol File: 25287-79-0.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 382°C at 760 mmHg
• Flash Point: 138.9°C
• Vapor Pressure: 4.89E-06mmHg at 25°C
• CAS DataBase Reference: 3-(dimethylamino)-1,2-diphenylpropan-1-one hydrochloride (1:1)(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(dimethylamino)-1,2-diphenylpropan-1-one hydrochloride (1:1)(25287-79-0)
• EPA Substance Registry System: 3-(dimethylamino)-1,2-diphenylpropan-1-one hydrochloride (1:1)(25287-79-0)

Safety Data

• Hazardous Substances Data: 25287-79-0(Hazardous Substances Data)

Upstream product

• 451-40-1 phenyl benzyl ketone 
• 30354-18-8 N,N-dimethyl(methylene)ammonium chloride 

Downstream Products

• 98617-20-0 1,2-Diphenyl-3-[1,2,4]triazol-1-yl-propan-1-one 
• 129286-87-9 5,6-Dihydro-2,3-diphenyl<1,10>phenanthroline 
• 4452-11-3 1,2-diphenylprop-2-en-1-one 
• 243445-17-2 2-(3-oxo-2,3-diphenyl-propyl)-cyclohexanone 
• 129286-90-4 2,3-Diphenyl-4,5-diazafluoren 
• 82132-58-9 2,3-diphenyl-5,6,7,8-tetrahydroquinoline 
• 65117-76-2 methyl 4,5-diphenyl-1H-pyrrole-2-carboxylate 

Relevant articles and documents

Efficient Preparation of Substituted 5,6,7,8-Tetrahydroquinolines and Octahydroacridine Derivatives

The reaction of the enamine 4 with different β-amino ketone hydrochlorides 3a-e affords the diketones 5a-e which can be cyclized to the corresponding mono- and disubstituted tetrahydroquinolines 6a-e. Furthermore the preparation of the octahydroacridines 8f and 8g by using a straightforward multi step sequence is described.

β-Amino Ketones as Key Intermediates in the Synthesis of Pyridines: A Novel and Efficient Route to Annelated Bi- and Terpyridines

The hydrochlorides of β-amino ketones 1a-e (Mannich bases) are easily obtained starting compounds for a novel synthesis of pyridines.Condensation with the heteroaromatic ketones 8, 9, and 10 yields 5,6-dihydro-1,10-phenanthrolines 3a-d, 13 and 4,5-diazafluorenes 4a-d, which have not yet been described in literature.Symmetrical terpyridines 3e, 4e are formed in a one-step reaction of 8, 9 with dimethylmethylenammonium chloride in the presence of an ammonia source.