252932-48-2

Basic information

• Product Name: 1H-Pyrrole-2-carboxylic acid, 3-amino-, ethyl ester
• Synonyms: 1H-Pyrrole-2-carboxylic acid, 3-amino-, ethyl ester;1H-Pyrrole-2-carboxylicacid,3-amino-,ethylester(9CI);3-Amino-1H-pyrrole-2-carboxylic acid ethyl ester
• CAS NO: 252932-48-2
• Molecular Formula: C₇H₁₀N₂O₂
• Molecular Weight: 154.17
• EINECS: 200-258-5
• Product Categories: GLYCINESCAFFOLD;CARBOXYLICESTER
• Mol File: 252932-48-2.mol
• Article Data: 15

Chemical Properties

• Boiling Point: 310.927 °C at 760 mmHg
• Flash Point: 141.844 °C
• Appearance: /
• Density: 1.239 g/cm³
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 15.93±0.50(Predicted)
• CAS DataBase Reference: 1H-Pyrrole-2-carboxylic acid, 3-amino-, ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Pyrrole-2-carboxylic acid, 3-amino-, ethyl ester(252932-48-2)
• EPA Substance Registry System: 1H-Pyrrole-2-carboxylic acid, 3-amino-, ethyl ester(252932-48-2)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 252932-48-2(Hazardous Substances Data)

Usage

Uses

Ethyl 3-amino-1H-pyrrole-2-carboxylate

Upstream product

• 1021175-71-2 diethyl 2-(2-cyanovinylamino)malonate 
• 288-14-2 ISOXAZOLE 
• 13433-00-6 diethyl aminomalonate hydrochloride 
• 252932-49-3 ethyl 3-amino-1H-pyrrole-2-carboxylate hydrochloride 
• 252932-49-3 3-amino-2-ethoxycarbonylpyrrole hydrochloride 

Downstream Products

• 5655-01-6 9-deazahypoxanthine 
• 410538-42-0 2-methyl-5-(3-nitro-phenyl)-1'H-[1,3']bipyrrolyl-3,2'-dicarboxylic acid diethyl ester 
• 890656-26-5 ethyl 3-amino-4-bromo-1H-pyrrole-2-carboxylate 
• 918331-14-3 3-bromopyrrolo[2,3-b]pyrrolizin-8(1H)-one 
• 410538-45-3 ethyl 5-(3-aminophenyl)-1-(pyrrol-3-yl)-2-methylpyrrole-2',3-dicarboxylate 
• 410538-48-6 ethyl 5-(3-azidophenyl)-1-(pyrrol-3-yl)-2-methylpyrrole-2',3-dicarboxylate 
• 252932-49-3 3-amino-2-ethoxycarbonylpyrrole hydrochloride 
• 939979-34-7 ethyl 3-ureido-1H-pyrrole-2-carboxylate 
• 1236764-55-8 3-(4-ethoxyphenyl)-2-thioxo-1,2,3,5-tetrahydro-4H-pyrrolo[3,2-d]pyrimidin-4-one 
• 1272674-03-9 ethyl 3-{[(4-fluorophenyl)acetyl]amino}-1H-pyrrole-2-carboxylate 
• 1272674-05-1 ethyl 3-({[4-(methyloxy)phenyl]acetyl}amino)-1H-pyrrole-2-carboxylate 
• 1272674-55-1 ethyl 3-amino-5-methyl-1-[4-(3-thienyl)phenyl]-1H-pyrrole-2-carboxylate 
• 1272674-56-2 ethyl 3-amino-5-chloro-1-[2'-fluoro-6'-(methyloxy)-4-biphenylyl]-1H-pyrrole-2-carboxylate 
• 1272674-59-5 ethyl 3-amino-5-cyano-1-(4-(thiophen-3-yl)phenyl)-1H-pyrrole-2-carboxylate 

Relevant articles and documents

Synthesis and antiviral activity of some 1H-pyrrolo[3,2-b]pyridin-6-yl)acetic acid derivatives

Pyrrolopyridine derivatives for the treatment of HIV1-infection were synthesized by 10 step reactions. Methyl 2-(3-bromo-7-(4-chlorophenyl)-1,5-dimethyl-1H-pyrrolo[3,2-b]pyridin-6-yl)-2-(tert-butoxy)acetate converted efficiently into the corresponding 1Hpyrrolo[3,2-b]pyridin-6-yl)acetic acid derivatives by Suzuki coupling reaction. Present procedure provides short reaction times and good to excellent yields for a wide range of compounds, including pyrrolopyridine scaffolds. 7-Halogenated 1H-pyrrolo[3,2,b]pyridine acetic acid derivatives of final products showed good activity inthe HIV-1 IN inhibition test, while the other derivatives showed relatively low activity.

HETEROAROMATIC NMDA RECEPTOR MODULATORS AND USES THEREOF

Disclosed herein, in part, are heteroaromatic compounds and methods of use in treating neuropsychiatric disorders, e.g., schizophrenia and major depressive disorder. Pharmaceutical compositions and methods of making heteroaromatic compounds are provided. The compounds are contemplated modulate the NMDA receptor.

Synthesis and reactivity of pyrrolo[3,2-d][1,3]oxazine-2,4-dione. Access to new pyrrolo[3,2-e][1,4]diazepine-2,5-diones

A convenient synthesis of pyrrolo[3,2-d][1,3]oxazine-2,4-dione 4 is described and its reactivity towards various nucleophiles studied. The regioselective ring opening of anhydride 4 or its N-alkylated analog 25 in the presence of alanine or proline afforded, respectively, imidazolidinedione 22 and N-protected pyrrolo[3,2-e][1,4]diazepines 30 and 31 in a one-pot process. In a last part of this study, an alternative route to produce a library of eight non protected pyrrolo[3,2-e][1,4]diazepine-2,5-diones 35a-h is described to overcome the limited reactivity of anhydride 4.