252987-03-4

Basic information

• Product Name: 5-{[(4-methoxybenzyl)oxy]methyl}-2,2,8-trimethyl-4H-[1,3]dioxino[4,5-c]pyridine
• Synonyms: 5-{[(4-methoxybenzyl)oxy]methyl}-2,2,8-trimethyl-4H-[1,3]dioxino[4,5-c]pyridine
• CAS NO: 252987-03-4
• Molecular Weight: 329.396
• Mol File: 252987-03-4.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 5-{[(4-methoxybenzyl)oxy]methyl}-2,2,8-trimethyl-4H-[1,3]dioxino[4,5-c]pyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 5-{[(4-methoxybenzyl)oxy]methyl}-2,2,8-trimethyl-4H-[1,3]dioxino[4,5-c]pyridine(252987-03-4)
• EPA Substance Registry System: 5-{[(4-methoxybenzyl)oxy]methyl}-2,2,8-trimethyl-4H-[1,3]dioxino[4,5-c]pyridine(252987-03-4)

Safety Data

• Hazardous Substances Data: 252987-03-4(Hazardous Substances Data)

Upstream product

• 1136-52-3 (2,2,8-trimethyl-4H-[1,3]dioxino[4,5-c]pyridin-5-yl)methanol 
• 824-94-2 p-methoxybenzyl chloride 

Downstream Products

• 1198621-14-5 methyl 5-((4-methoxybenzyloxy)methyl)-2,2-dimethyl-4H-[1,3]dioxino[4,5-c]pyridine-8-carboxylate 
• 1198621-15-6 methyl 3-hydroxy-4-(hydroxymethyl)-5-((4-methoxybenzyloxy)methyl)picolinate 
• 280762-70-1 2-(trimethylsilyl) ethyl-3-[3-(benzyloxy)-4-(chloromethyl)-5-(hydroxymethyl)-2-pyridinyl]propanoate 
• 280762-57-4 (3-(benzyloxy)-5-{[(4-methoxybenzyl)oxy]methyl}-2-methyl-4-pyridinyl)methanol 
• 280762-69-8 acetic acid 5-benzyloxy-4-chloromethyl-6-methyl-pyridin-3-ylmethyl ester 
• 280762-68-7 [5-(benzyloxy)-4-(chloromethyl)-6-methyl-3-pyridinyl]methanol 
• 280762-79-0 5-((4-methoxybenzyloxy)methyl)-2,2-dimethyl-4H-[1,3]dioxino[4,5-c]pyridine-8-carboxylic acid 
• 252987-07-8 (3-(benzyloxy)-5-{[(4-methoxybenzyl)oxy]methyl}-4-pyridinyl)methanol 
• 252987-04-5 (5-{[(4-methoxybenzyl)oxy]methyl}-2,2-dimethyl-4H-[1,3]dioxino[4,5-c]pyridin-8-yl)methanol 
• 280762-58-5 5-{[(4-methoxybenzyl)oxy]methyl}-2,2-dimethyl-4H-[1,3]dioxino[4,5-c]pyridine-8-carbaldehyde 
• 252987-05-6 5-{[(4-methoxybenzyl)oxy]methyl}-2,2-dimethyl-4H-[1,3]dioxino[4,5-c]pyridine 
• 252987-06-7 4-(hydroxymethyl)-5-{[(4-methoxybenzyl)oxy]methyl}-3-pyridinol 

Relevant articles and documents

Transformation of vitamin B6 to (+)-deoxypyridinoline, a useful biochemical marker for diagnosis of bone diseases

A versatile chiral synthesis of the cross-link (+)-deoxypyridinoline (Dpd, 2) was achieved starting from vitamin B6 (7). The key steps in the synthesis of (+)-2 are transformation of B6 (7) to the chloride (3d) and construction of three α-amino acid chains by utilizing (R)-(-)-Schollkopf's reagent (4), Wittig reagent (R)-(-)-5, and iodide (5)-(-)-6. (+)-Dpd (2) is a degradation product of bone collagen and has been found to be a useful marker for diagnosis of osteoporosis and other metabolic bone diseases. (C) 2000 Elsevier Science Ltd.

HIV INTEGRASE INHIBITORS FROM PYRIDOXINE

The present invention relates to pyridoxine (vitamin B6) derived compounds of formula (I), pharmaceutically acceptable salts, or solvates thereof, wherein R1, R2, R4, A, L B1 and B2 are as defined in the specification, and pharmaceutical compositions comprising the compounds. Compounds of formula (I) inhibit Human Immunodeficiency Virus (HΙV)-integrase enzyme and are useful for preventing and treating HIV infection and AIDS.