25314-91-4Relevant articles and documents
Controlling chemoselectivity-application of DMF di-t-butyl acetal in the regioselective synthesis of 3-monosubstituted indolizines
Xia, Zhiqiang,Przewloka, Teresa,Koya, Keizo,Ono, Mitsunori,Chen, Shoujun,Sun, Lijun
, p. 8817 - 8820 (2006)
Among a number of DMF dialkyl acetals investigated for the regioselective synthesis of 3-acylindolizines, the di-t-butyl acetal, via its iminium intermediate readily formed in situ, provides the highest chemoselectivity for the intermolecular cyclization of picolinium salts. DMF di-t-butyl acetal was applied to the syntheses of a variety of 3-acylated indolizines including alkyl, aryl, and heteroaryl substituents.
Plladium-catalyzed arylation and heteroarylation of indolizines
Park, Choul-Hong,Ryabova, Victoria,Seregin, Ilya V.,Sromek, Anna W.,Gevorgyan, Vladimir
, p. 1159 - 1162 (2007/10/03)
A highly effective protocol for palladium-catalyzed selective arylation and heteroarylation of indolizines at C-3 has been developed. Mechanistic studies unambiguously support an electrophilic substitution pathway for this transformation.
A new approach for the synthesis of fused pyrroles. The synthesis of acyl substituted pyrrolo[1,2-x]azines
Copar,Stanovnik,Tisler
, p. 1577 - 1580 (2007/10/02)
N-Acetonyl- and N-phenacyl quaternary salts of α-methyl substituted heterocycles 16, 17, 21, 23 and 26 were converted with DMFDMA into the corresponding 3-acylpyrrolo[1,2-a]pyridine 18, 7-benzoylpyrrolo[1,2- c]pyrimidine 22, and 6-benzoylpyrrolo[1,2-a]pyrazine derivatives 24 and 27. A concurrent reaction produced methyl and phenyl substituted pyrrolo[1,2- x]azines 19, 20, 25 and 28.
