253168-83-1 Usage
Description
1H-Isoindole-1,3(2H)-dione, 2-[1-(3-ethoxy-4-Methoxyphenyl)-2-(Methylsulfonyl)ethyl]is a chemical compound that is used in the preparation of apremilast acetylamino analogs. It functions as an oral phosphodiesterase 4 (PDE4) and tumor necrosis factor-alpha (TNF-α) inhibitor.
Uses
Used in Pharmaceutical Industry:
1H-Isoindole-1,3(2H)-dione, 2-[1-(3-ethoxy-4-Methoxyphenyl)-2-(Methylsulfonyl)ethyl]is used as an intermediate in the synthesis of apremilast acetylamino analogs for the development of oral PDE4 and TNF-α inhibitors. These inhibitors play a crucial role in managing inflammatory diseases by regulating the immune response and reducing inflammation.
Check Digit Verification of cas no
The CAS Registry Mumber 253168-83-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,5,3,1,6 and 8 respectively; the second part has 2 digits, 8 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 253168-83:
(8*2)+(7*5)+(6*3)+(5*1)+(4*6)+(3*8)+(2*8)+(1*3)=141
141 % 10 = 1
So 253168-83-1 is a valid CAS Registry Number.
253168-83-1Relevant articles and documents
Methods for preparation of apremilast
-
, (2021/05/19)
The present invention discloses a method for preparation of Apremilast. β-phthalimino vinylsulfones are reacted through the asymmetric addition reaction to form an addition product, and the drug of Apremilast can be obtained from the addition product through simple reactions. The method is a process for synthesizing Apremilast in a more efficient way.
Substituted phenethylsulfones and method of reducing TNF alpha levels
-
, (2008/06/13)
Phenethylsulfones substituted in the position alpha to the phenyl group with a 1-oxoisoindoline or 1,3-dioxoisoindoline group reduce the levels of TNF alpha in a mammal. Typical embodiments are 2-[1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-aminoisoindoline-1,3-dione and 2-[1-(3-cyclopentyloxy-4-methoxyphenyl)-2-methylsulfonylethyl]isoindoline-1,3-dione.
