253175-89-2

Basic information

• Product Name: C₄₁H₄₈N₆O₉
• CAS NO: 253175-89-2
• Molecular Weight: 768.867
• Mol File: 253175-89-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₄₁H₄₈N₆O₉(CAS DataBase Reference)
• NIST Chemistry Reference: C₄₁H₄₈N₆O₉(253175-89-2)
• EPA Substance Registry System: C₄₁H₄₈N₆O₉(253175-89-2)

Safety Data

• Hazardous Substances Data: 253175-89-2(Hazardous Substances Data)

Upstream product

• 253175-09-6 C₂₄H₂₆N₄O₇ 
• 3282-30-2 pivaloyl chloride 
• 253175-88-1 4-(2,2-dimethyl-propionyl)-piperazine-1-carbonyl chloride 
• 253175-11-0 C₃₁H₃₂N₄O₇ 
• 253175-05-2 (2S,3R)-3-(3-azidopropyl)-4-oxoazetidine-2-carboxylic acid 
• 253175-07-4 (2S,3R)-3-(3-chloropropyl)-4-oxoazetidine-2-carboxylic acid 
• 911852-44-3 (2S,3R)-3-(3-aminopropyl)-4-oxoazetidine-2-carboxylic acid 
• 155295-47-9 2,2-dimethyl-1-(piperazin-1-yl)propan-1-one 

Relevant articles and documents

Synthesis and SAR of 4-carboxy-2-azetidinone mechanism-based tryptase inhibitors

A series of N1-activated C4-carboxy azetidinones was prepared and tested as inhibitors of human tryptase. The key stereochemical and functional features required for potency, serine protease specificity and aqueous stability were determined. From these studies compound 2, BMS-262084, was identified as a potent and selective tryptase inhibitor which, when dosed intratracheally in ovalbumin-sensitized guinea pigs, reduced allergen-induced bronchoconstriction and inflammatory cell infiltration into the lung.