253178-21-1

Basic information

• Product Name: ethyl (R)-2-amino-3,3-dimethylbutanoate
• Synonyms: ethyl (R)-2-amino-3,3-dimethylbutanoate
• CAS NO: 253178-21-1
• Molecular Weight: 159.228
• Mol File: 253178-21-1.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 185.7±13.0 °C(Predicted)
• Density: 0.946±0.06 g/cm3(Predicted)
• CAS DataBase Reference: ethyl (R)-2-amino-3,3-dimethylbutanoate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl (R)-2-amino-3,3-dimethylbutanoate(253178-21-1)
• EPA Substance Registry System: ethyl (R)-2-amino-3,3-dimethylbutanoate(253178-21-1)

Safety Data

• Hazardous Substances Data: 253178-21-1(Hazardous Substances Data)

Upstream product

• 62965-34-8 Trimethylpyruvic acid oxime 
• 507229-71-2 2-((R)-2-Methoxy-1-phenyl-ethylamino)-3,3-dimethyl-butyric acid ethyl ester 
• 64-17-5 ethanol 
• 33105-81-6 2-amino-3,3-dimethylbutanoic acid 

Downstream Products

• 26782-71-8 D-tert-leucine 

Relevant articles and documents

Branch-Selective Addition of Unactivated Olefins into Imines and Aldehydes

Radical hydrofunctionalization occurs with ease using metal-hydride hydrogen atom transfer (MHAT) catalysis to couple alkenes and competent radicalophilic electrophiles. Traditional two-electron electrophiles have remained unreactive. Herein we report the reductive coupling of electronically unbiased olefins with imines and aldehydes. Iron catalysis allows addition of alkyl-substituted olefins into imines through the intermediacy of free radicals, whereas a combination of catalytic Co(Salt-Bu,t-Bu) and chromium salts enables a branch-selective coupling of olefins and aldehydes through the formation of a putative alkyl chromium intermediate.