253192-28-8

Basic information

• Product Name: 4-(1-benzyl-piperidin-4-ylamino)-benzoic acid tert-butyl ester
• Synonyms: 4-(1-benzyl-piperidin-4-ylamino)-benzoic acid tert-butyl ester
• CAS NO: 253192-28-8
• Molecular Weight: 366.503
• Mol File: 253192-28-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-(1-benzyl-piperidin-4-ylamino)-benzoic acid tert-butyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(1-benzyl-piperidin-4-ylamino)-benzoic acid tert-butyl ester(253192-28-8)
• EPA Substance Registry System: 4-(1-benzyl-piperidin-4-ylamino)-benzoic acid tert-butyl ester(253192-28-8)

Safety Data

• Hazardous Substances Data: 253192-28-8(Hazardous Substances Data)

Upstream product

• 619-42-1 4-methoxycarbonylphenyl bromide 
• 50541-93-0 4-amino-1-benzylpiperidine 
• 59247-47-1 tert-butyl-4-bromobenzoate 

Downstream Products

• 253192-29-9 tert-butyl 4-(piperidin-4-ylamino)benzoate 
• 253191-97-8 4-(1-Pyrimidin-2-ylpiperidin-4-ylamino)benzoic acid tert-butyl ester 
• 253191-94-5 4-(1-naphthalen-2-ylpiperidin-4-ylamino)benzoic acid tert-butyl ester 
• 253191-95-6 4-[1-(Naphthalene-2-sulfonyl)-piperidin-4-ylamino]benzoic acid tert-butyl ester 
• 253191-98-9 4-[1-(5-Methoxy-1H-benzoimidazol-2-yl)piperidin-4-ylamino]benzoic acid tert-butyl ester 
• 253191-96-7 4-[1-(Naphthalene-2-carbonyl)-piperidin-4-ylamino]-benzoic acid tert-butyl ester 
• 253192-03-9 4-[1-(4-Aminoquinazolin-2-yl)piperidin-4-ylamino]benzoic acid tert-butyl ester 
• 253191-99-0 4-[1-(6,7-Dimethoxyquinazolin-2-yl)piperidin-4-ylamino]benzoic acid tert-butyl ester 
• 253192-01-7 4-[1-(4-hydroxy-6,7-dimethoxy-quinazolin-2-yl)-piperidin-4-ylamino]-benzoic acid tert-butyl ester 
• 253192-00-6 4-[1-(4,6,7-Trimethoxyquinazolin-2-yl)piperidin-4-ylamino]benzoic acid tert-butyl ester 
• 253191-91-2 4-[1-(4-Amino-6,7-dimethoxy-quinazolin-2-yl)-piperidin-4-ylamino]-benzoic acid tert-butyl ester 
• 253192-02-8 4-[1-(6,7-Dimethoxy-4-p-tolylaminoquinazolin-2-yl)piperidin-4-ylamino]benzoic acid tert-butyl ester 

Relevant articles and documents

Structure-activity relationships of novel 2-substituted quinazoline antibacterial agents

High-throughput screening of in-house compound libraries led to the discovery of a novel antibacterial agent, compound 1 (MIC: 12-25 μM against S. pyogenes). In an effort to improve the activity of this active compound, a series of 2-substituted quinazolines was synthesized and evaluated in several antibacterial assays. One such compound (22) displayed improved broad- spectrum antibacterial activity against a variety of bacterial strains. This molecule also inhibited transcription/translation of bacterial RNA, suggesting a mechanism for its antibiotic effects. Structure-activity relationship studies of 22 led to the synthesis of another 24 compounds. Although some of these molecules were found to be active in bacterial growth assays, none were as potent as 22. Compound 22 was tested for its ability to cure a systemic K. pneumonia infection in the mouse and displayed moderate effects compared with a control antibiotic, gentamycin.