253276-09-4

Basic information

• Product Name: (+)-(4-isobutyl-phenyl)-acetic acid (1S,2S)-2-(naphthalene-2-sulfonyl)-cyclohexyl ester
• Synonyms: (+)-(4-isobutyl-phenyl)-acetic acid (1S,2S)-2-(naphthalene-2-sulfonyl)-cyclohexyl ester
• CAS NO: 253276-09-4
• Molecular Weight: 464.626
• Mol File: 253276-09-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (+)-(4-isobutyl-phenyl)-acetic acid (1S,2S)-2-(naphthalene-2-sulfonyl)-cyclohexyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (+)-(4-isobutyl-phenyl)-acetic acid (1S,2S)-2-(naphthalene-2-sulfonyl)-cyclohexyl ester(253276-09-4)
• EPA Substance Registry System: (+)-(4-isobutyl-phenyl)-acetic acid (1S,2S)-2-(naphthalene-2-sulfonyl)-cyclohexyl ester(253276-09-4)

Safety Data

• Hazardous Substances Data: 253276-09-4(Hazardous Substances Data)

Upstream product

• 253275-87-5 (1S,2S)-2-(naphthalene-2-ylsulfanyl)cyclohexanol 
• 91-60-1 2-Naphthalenethiol 
• 286-20-4 cyclohexane-1,2-epoxide 
• 253275-89-7 (+)-(1S,2S)-2-(naphthalene-2-sulfonyl)cyclohexanol 
• 1553-60-2 ibufenac 

Downstream Products

• 253276-16-3 (+)-(S)-2-(4-isobutyl-phenyl)-propionic acid (1S,2S)-2-(naphthalene-2-sulfonyl)-cyclohexyl ester 
• 81576-55-8 (S)-(+)-methyl 2-(4-isobutylphenyl)propionate 
• 51146-56-6 (S)-ibuprofen 

Relevant articles and documents

A practical new chiral controller for asymmetric Diels-Alder and alkylation reactions

(formula presented) The enantiomerically pure hydroxy sulfones (+)- and (-)-2 have been prepared from 1,2-epoxycyclohexane by a simple and practical procedure. The acrylate esters of these alcohols undergo BCl3-catalyzed Diels-Alder reactions with a variety of dienes at -78 to -55°C in CH2Cl2 or C7H8 with high dienophile face selectivity (Table 1). The chiral esters so formed are readily cleaved with recovery of the controllers (+)- or (-)-2. Esters of (+)- and (-)-2 can be converted to Z-polassium enolates and alkylated with high face selectivity.