253328-67-5

Basic information

• Product Name: 2-(3-(trifluoromethyl)phenyl)-[1,2,4]triazolo[1,5-a]pyridine
• Synonyms: 2-(3-(trifluoromethyl)phenyl)-[1,2,4]triazolo[1,5-a]pyridine
• CAS NO: 253328-67-5
• Molecular Weight: 263.222
• Mol File: 253328-67-5.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 2-(3-(trifluoromethyl)phenyl)-[1,2,4]triazolo[1,5-a]pyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(3-(trifluoromethyl)phenyl)-[1,2,4]triazolo[1,5-a]pyridine(253328-67-5)
• EPA Substance Registry System: 2-(3-(trifluoromethyl)phenyl)-[1,2,4]triazolo[1,5-a]pyridine(253328-67-5)

Safety Data

• Hazardous Substances Data: 253328-67-5(Hazardous Substances Data)

Upstream product

• 504-29-0 2-aminopyridine 
• 368-77-4 3-trifluoromethylbenzonitrile 

Relevant articles and documents

An efficient and recyclable heterogeneous catalytic system for the synthesis of 1,2,4-triazoles using air as the oxidant

Copper-zinc supported on Al2O3-TiO2 was found as a simple and efficient heterogeneous catalyst for the oxidative synthesis of 1,2,4-triazole derivatives using air as the green oxidant under ligand-, base- and additive-free conditions. The heterogeneous reactions carried out smoothly with a large range of substrates, including NO2-, vinyl-, pyrimidine- and imidazole-contained starting materials, and provided corresponding triazoles in moderate to excellent yields with low catalyst loading (1.6 mol%). Furthermore, the catalyst can be simply recycled many times without significant loss in catalytic activity. The Royal Society of Chemistry.

Facile synthesis of 1,2,4-triazoles via a copper-catalyzed tandem addition-oxidative cyclization

A simple one-step synthesis of 1,2,4-triazole derivatives is provided by a copper-catalyzed oxidative coupling reaction under an atmosphere of air. The process should consist of sequential N-C and N-N bond-forming copper-catalyzed oxidative coupling reactions. Starting materials and the copper catalyst are readily available and inexpensive. A wide range of functional groups are tolerated to achieve chemical diversity.