25343-32-2

Basic information

• Product Name: 1-(2-ISOPROPYLPHENYL)-2-THIOUREA
• Synonyms: N-(2-ISOPROPYLPHENYL)THIOUREA;1-(2-ISOPROPYLPHENYL)-2-THIOUREA;1-(2-ISOPROPYLPHENYL)PROPIONIC ACID
• CAS NO: 25343-32-2
• Molecular Formula: C₁₀H₁₄N₂S
• Molecular Weight: 194.3
• Mol File: 25343-32-2.mol
• Article Data: 6

Chemical Properties

• Melting Point: 128-130°C
• Boiling Point: 296.7°C at 760 mmHg
• Flash Point: 133.2°C
• Appearance: /
• Density: 1.159g/cm³
• Vapor Pressure: 0.00141mmHg at 25°C
• Refractive Index: 1.646
• PKA: 13.10±0.70(Predicted)
• CAS DataBase Reference: 1-(2-ISOPROPYLPHENYL)-2-THIOUREA(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2-ISOPROPYLPHENYL)-2-THIOUREA(25343-32-2)
• EPA Substance Registry System: 1-(2-ISOPROPYLPHENYL)-2-THIOUREA(25343-32-2)

Safety Data

• Hazardous Substances Data: 25343-32-2(Hazardous Substances Data)

Usage

General Description

1-(2-Isopropylphenyl)-2-thiourea is a chemical compound with the molecular formula C11H16N2S. It is a white crystalline solid that is commonly used as a source of sulfur in organic synthesis. 1-(2-Isopropylphenyl)-2-thiourea has a variety of applications, including as a reagent in the production of pharmaceuticals, agrochemicals, and dyes. It is also used as a rubber accelerator in the production of tires. Additionally, this compound has potential anti-cancer properties and is being studied for its ability to inhibit the growth of cancer cells. Overall, 1-(2-Isopropylphenyl)-2-thiourea is a versatile chemical with a range of industrial and medicinal applications.

InChI:InChI=1/C10H14N2S/c1-7(2)8-5-3-4-6-9(8)12-10(11)13/h3-7H,1-2H3,(H3,11,12,13)

Upstream product

• 25343-23-1 N-((2-isopropylphenyl)carbamothioyl)benzamide 
• 36176-31-5 1-isopropyl-2-isothiocyanatobenzene 
• 643-28-7 2-isopropylaniline 
• 102439-84-9 2-isopropyl-aniline; hydrochloride 

Downstream Products

• 88884-43-9 1-(2-Isopropyl-phenyl)-2-methyl-isothiourea; hydriodide 
• 88884-53-1 N-(2-Isopropyl-phenyl)-pyrrolidine-1-carboxamidine; hydriodide 
• 88884-54-2 N-(2-Isopropyl-phenyl)-morpholine-4-carboxamidine; hydriodide 
• 1417885-44-9 N-[[(2-isopropylphenyl)amino]thioxomethyl]N'-(2-methyl(4-(1-(4-(trifluoromethoxy)phenyl)-1H-1,2,4-triazol-3-yl)phenyl))urea 
• 1417885-36-9 N-[[(2-isopropylphenyl)amino]thioxomethyl]-N'-((4-(1-(4-(trifluoromethoxy)phenyl)-1H-pyrazol-3-yl)phenyl))urea 
• 1417885-18-7 N-[[(2-isopropylphenyl)amino]thioxomethyl]N'-((4-(5-(4-(perfluoroethoxy)phenyl)-1,3,4-oxadiazol-2-yl)phenyl))urea 

Relevant articles and documents

Search for the Active Ingredients from a 2-Aminothiazole DMSO Stock Solution with Antimalarial Activity

Chemical decomposition of DMSO stock solutions is a common incident that can mislead biological screening campaigns. Here, we share our case study of 2-aminothiazole 1, originating from an antimalarial class that undergoes chemical decomposition in DMSO at room temperature. As previously measured biological activities observed against Plasmodium falciparum NF54 and for the target enzyme PfIspE were not reproducible for a fresh batch, we tackled the challenge to understand where the activity originated from. Solvent- and temperature-dependent studies using HRMS and NMR spectroscopy to monitor the decomposition led to the isolation and in vitro evaluation of several fractions against PfIspE. After four days of decomposition, we successfully isolated the oxygenated and dimerised compounds using SFC purification and correlated the observed activities to them. Due to the unstable nature of the two isolates, it is likely that they undergo further decomposition contributing to the overall instability of the compound.

Synthesis of thiophene-2-carboxamidines containing 2-aminothiazoles and their biological evaluation as urokinase inhibitors

The serine protease urokinase (uPa) has been implicated in the progression of both breast and prostate cancer. Utilizing structure based design, the synthesis of a series of substituted 4-[2-amino-1,3-thiazolyl]-thiophene-2-carboxamidines is described. Further optimization of this series by substitution of the terminal amine yielded urokinase inhibitors with excellent activities.

Improved Procedures for the Preparation of Cycloalkyl-, Arylalkyl-, and Arylthioureas

An improved procedure for the preparation of arylthioureas consists of the reaction of benzoyl isothiocyanate with anilines in acetone and debenzoylation of the resultant N-aryl-N'-benzoylthioureas with 5percent aqueous sodium hydroxide.Bicycloalkylthioureas and N-(arylalkyl)thioureas (e.g. 9H-9-fluorenylthiourea) are directly prepared from the corresponding isothiocyanates and ammonia.