253446-34-3

Basic information

• Product Name: 1-Piperazinecarboxylic acid, 4-phenyl-, ethyl ester
• CAS NO: 253446-34-3
• Molecular Formula: C13H18N2O2
• Molecular Weight: 234.298
• Mol File: 253446-34-3.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 1-Piperazinecarboxylic acid, 4-phenyl-, ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Piperazinecarboxylic acid, 4-phenyl-, ethyl ester(253446-34-3)
• EPA Substance Registry System: 1-Piperazinecarboxylic acid, 4-phenyl-, ethyl ester(253446-34-3)

Safety Data

• Hazardous Substances Data: 253446-34-3(Hazardous Substances Data)

Usage

Ester derived from

piperazinecarboxylic acid and ethyl alcohol

Contains

a phenyl group

Widely used in

pharmaceutical industry

Used as

intermediate in the synthesis of various drugs

Applications

building block in the production of antihistamines, antipsychotic drugs, and antidepressants; manufacturing of agricultural products and dyes

Toxicity

moderate, precautions should be taken when handling it.

Upstream product

• 120-43-4 4-ethoxycarbonylpiperazine 
• 108-90-7 chlorobenzene 
• 92-54-6 4-phenyl-1-piperazine 
• 541-41-3 chloroformic acid ethyl ester 
• 4004-95-9 1-phenylpiperazine hydrochloride 

Downstream Products

• 477708-49-9 4-[4'-(prop-1-yn-3-ol)-phenyl]-piperazine-1-carboxylic acid ethyl ester 
• 477708-47-7 4-[4'-(prop-1-yn-3-al)-phenyl]-piperazine-1-carboxylic acid ethyl ester 
• 477708-48-8 4-(4'-iodophenyl)-piperazine-1-carboxylic acid ethyl ester 
• 18722-00-4 4-phenyl-piperazine-1-carboxylic acid-(2-diethylamino-ethyl ester) 

Relevant articles and documents

Synthesis of thermotropic liquid crystals derived from phenylpiperazine containing an enyne unit

Thermotropic liquid crystals are of great technological importance. Much research is devoted to the development of stable compounds with transition temperatures close to room temperature. The interest of this work is the synthesis of thermotropic liquid crystal precursor units containing phenylpiperazine and/or phenylacetylenic units. Homologues of a Schiff base series and an enyne series have been synthesized, allowing comparisons of their mesomorphic and thermodynamic properties. The Schiff bases showed smectogenic behavior and the enynes a smectic dimorphism and/or a nematic phase. The synthetic methodology was efficient for the synthesis of the desired precursor, 4-[4′-(prop-l-yn-3-al)phenyl]-piperazine-l-carboxylic acid ethyl ester.