25357-42-0Relevant articles and documents
Facile one-pot tandem synthesis of perfluoroalkylated indolizines under metal-free mild conditions
He, Dong,Xu, Yuhong,Han, Jing,Deng, Hongmei,Shao, Min,Chen, Jie,Zhang, Hui,Cao, Weiguo
, p. 938 - 944 (2017)
A direct metal-free method for the synthesis of perfluoroalkylated indolizines by means of DIPEA-promoted tandem C[sbnd]N/C[sbnd]C bond formation was developed. Various substituted pyridines and bromoacetyl derivatives with methyl perfluoroalk-2-ynoates proceeded smoothly in this mild transformation, and the desired products were obtained in good to excellent yields under air.