253663-85-3

Basic information

• Product Name: 3-benzenesulfonyl-6-chloro-4-trifluoromethyl-1H-quinolin-2-one
• Synonyms: 3-benzenesulfonyl-6-chloro-4-trifluoromethyl-1H-quinolin-2-one
• CAS NO: 253663-85-3
• Molecular Weight: 387.767
• Mol File: 253663-85-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3-benzenesulfonyl-6-chloro-4-trifluoromethyl-1H-quinolin-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3-benzenesulfonyl-6-chloro-4-trifluoromethyl-1H-quinolin-2-one(253663-85-3)
• EPA Substance Registry System: 3-benzenesulfonyl-6-chloro-4-trifluoromethyl-1H-quinolin-2-one(253663-85-3)

Safety Data

• Hazardous Substances Data: 253663-85-3(Hazardous Substances Data)

Upstream product

• 253663-82-0 3-benzenesulfonyl-6-chloro-4-hydroxy-4-trifluoromethyl-3,4-dihydro-1H-quinolin-2-one 
• 253668-48-3 2-Bromo-N-[4-chloro-2-(2,2,2-trifluoro-acetyl)-phenyl]-acetamide 
• 154598-53-5 1-(2-amino-5-chloro-phenyl)-2,2,2-trifluoro-ethanone 
• 873-55-2 sodium benzenesulfonate 

Downstream Products

• 364360-72-5 3-(4-amino-3-fluoro-benzyloxy)-6-chloro-4-cyclopropylethynyl-4-trifluoromethyl-1-(2-trimethylsilanyl-ethoxymethyl)-3,4-dihydro-1H-quinolin-2-one 
• 364360-70-3 3-(3-amino-benzyloxy)-6-chloro-4-cyclopropylethynyl-4-trifluoromethyl-1-(2-trimethylsilanyl-ethoxymethyl)-3,4-dihydro-1H-quinolin-2-one 
• 364360-69-0 3-(2-amino-benzyloxy)-6-chloro-4-cyclopropylethynyl-4-trifluoromethyl-1-(2-trimethylsilanyl-ethoxymethyl)-3,4-dihydro-1H-quinolin-2-one 
• 364360-71-4 3-(4-amino-benzyloxy)-6-chloro-4-cyclopropylethynyl-4-trifluoromethyl-1-(2-trimethylsilanyl-ethoxymethyl)-3,4-dihydro-1H-quinolin-2-one 
• 364360-66-7 6-chloro-4-cyclopropylethynyl-3-(2-fluoro-benzyloxy)-4-trifluoromethyl-1-(2-trimethylsilanyl-ethoxymethyl)-3,4-dihydro-1H-quinolin-2-one 
• 364360-67-8 6-chloro-4-cyclopropylethynyl-3-(3-fluoro-benzyloxy)-4-trifluoromethyl-1-(2-trimethylsilanyl-ethoxymethyl)-3,4-dihydro-1H-quinolin-2-one 
• 364360-73-6 3-benzylamino-6-chloro-4-cyclopropylethynyl-1-(4-methoxy-benzyl)-4-trifluoromethyl-3,4-dihydro-1H-quinolin-2-one 
• 364360-62-3 3-benzyloxy-6-chloro-4-cyclopropylethynyl-4-trifluoromethyl-1-(2-trimethylsilanyl-ethoxymethyl)-3,4-dihydro-1H-quinolin-2-one 
• 364360-74-7 [6-chloro-4-cyclopropylethynyl-1-(4-methoxy-benzyl)-2-oxo-4-trifluoromethyl-1,2,3,4-tetrahydro-quinolin-3-yl]-carbamic acid methyl ester 
• 364360-75-8 N-[6-chloro-4-cyclopropylethynyl-1-(4-methoxy-benzyl)-2-oxo-4-trifluoromethyl-1,2,3,4-tetrahydro-quinolin-3-yl]-acetamide 
• 364360-76-9 3-amino-6-chloro-4-cyclopropylethynyl-1-(4-methoxy-benzyl)-4-trifluoromethyl-3,4-dihydro-1H-quinolin-2-one 
• 364360-40-7 3-azido-6-chloro-4-cyclopropylethynyl-1-(4-methoxy-benzyl)-4-trifluoromethyl-3,4-dihydro-1H-quinolin-2-one 

Relevant articles and documents

Synthesis and evaluation of novel quinolinones as HIV-1 reverse transcriptase inhibitors

A series of 4,4-disubstituted quinolinones was prepared and evaluated as HIV-1 reverse transcriptase inhibitors. The C-3 substituted compound 9h displayed improved antiviral activity against clinically significant single (K103N) and double (K103N/L100I) mutant viruses.