25371-98-6

Basic information

• Product Name: 1-(4-TRIFLUOROMETHYLPHENYL)IMIDAZOLE
• Synonyms: 1-[4-(Trifluoromethyl)phenyl]-1H-imidazole;1-[4-(Trifluoromethyl)phenyl]imidazole 99%;1-[4-(Trifluoromethyl)phenyl]imidazole99%;1-(4-TRIFLUOROMETHYLPHENYL)IMIDAZOLE
• CAS NO: 25371-98-6
• Molecular Formula: C₁₀H₇F₃N₂
• Molecular Weight: 212.17
• Product Categories: Imidazol&Benzimidazole
• Mol File: 25371-98-6.mol
• Article Data: 58

Chemical Properties

• Melting Point: 71 °C
• Boiling Point: 90 °C
• Flash Point: 119.6 °C
• Appearance: /
• Density: 1.27 g/cm³
• Vapor Pressure: 0.00918mmHg at 25°C
• Refractive Index: 1.522
• PKA: 4.99±0.10(Predicted)
• CAS DataBase Reference: 1-(4-TRIFLUOROMETHYLPHENYL)IMIDAZOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-TRIFLUOROMETHYLPHENYL)IMIDAZOLE(25371-98-6)
• EPA Substance Registry System: 1-(4-TRIFLUOROMETHYLPHENYL)IMIDAZOLE(25371-98-6)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• HazardClass: IRRITANT
• Hazardous Substances Data: 25371-98-6(Hazardous Substances Data)

Usage

General Description

1-(4-Trifluoromethylphenyl)imidazole is a chemical compound that belongs to the imidazole class of substances. Imidazoles are known for being versatile intermediates in organic synthesis. This particular chemical has a trifluoromethyl functional group attached to the phenyl ring, which is often used in medicinal chemistry due to its lipophilic properties, stability and bioavailability. Its CAS number is 2154-38-3. The physical and chemical properties, safety, toxicity, potential applications or uses of 1-(4-Trifluoromethylphenyl)imidazole in specific industries or research haven't been extensively studied or reported in literature as it's largely considered an intermediate for other chemical reactions.

InChI:InChI=1/C10H7F3N2/c11-10(12,13)8-1-3-9(4-2-8)15-6-5-14-7-15/h1-7H

Upstream product

• 288-32-4 1H-imidazole 
• 128796-39-4 4-trifluoromethylphenylboronic acid 
• 98-56-6 4-chlorobenzotrifluoride 
• 455-13-0 4-Iodobenzotrifluoride 
• 402-43-7 p-trifluoromethylphenyl bromide 
• 402-45-9 4-hydroxybenzotrifluoride 
• 34857-71-1 4-trifluoromethylphenyl N,N-diethylcarbamate 
• 1201594-37-7 (4-[trifluoromethyl]phenyl) N,N-dimethylsulfamate 

Downstream Products

• 444348-62-3 2-[(5-chloro-2-methoxyphenyl)methyl]-1-[4-(trifluoromethyl)phenyl]-1H-imidazole 
• 1235961-86-0 [(1-(prop-2-ynyl)-3-(4-trifluoromethylphenyl))imidazolium] bromide 
• 1262662-74-7 [1-(2-pyridyl)methylene-3-(4-trifluoromethylphenyl)]imidazolium bromide 
• 1428261-69-1 C₁₁H₁₀F₃N₂⁽¹⁺⁾*I^(1-) 

Relevant articles and documents

L-Proline N-oxide dihydrazides as an efficient ligand for cross-coupling reactions of aryl iodides and bromides with amines and phenols

A novel catalytic system based on L-proline N-oxide/CuI was developed and applied to the cross-coupling reactions of various N- and O- nucleophilic reagents with aryl iodides and bromides. This strategy featured in the employment of an-proline derived dihydrazides N-oxide compound as the superior supporting ligand. By using this protocol, a variety of products, including N-arylimidazoles, N-arylpyrazoles, N-arylpyrroles, N-arylamines, and aryl ethers, were synthesized with up to 99% yield.

N -Arylation of (hetero)arylamines using aryl sulfamates and carbamates via C-O bond activation enabled by a reusable and durable nickel(0) catalyst

An effective and general aryl amination protocol has been developed using a magnetically recoverable Ni(0) based nanocatalyst. This new stable catalyst was prepared on Fe3O4@SiO2 modified by EDTA and investigated by FT-IR, EDX, TEM, XRD, DLS, FE-SEM, XPS, NMR, TGA, VSM, ICP and elemental analysis techniques. The reaction proceeded via carbon-oxygen bond cleavage of (hetero)aryl carbamates and sulfamates under simple and mild conditions without the use of any external ligands. This method demonstrated functional group tolerance in the N-arylation of various nitrogen-containing compounds as well as aliphatic amines, anilines, pyrroles, pyrazoles, imidazoles, indoles, and indazoles with good to excellent yields. Furthermore, the catalyst could be easily recovered by using an external magnetic field and directly reused at least six times without notable reduction in its activity. This journal is

Highly-efficient N-arylation of imidazole catalyzed by Cu(II) complexes with quaternary ammonium-functionalized 2-acetylpyridine acylhydrazone

The reaction of (E)-N,N,N-trimethyl-2-oxo-2-(2-(1-(pyridin-2-yl)ethylidene)hydrazinyl)ethan-1-aminium-chloride (HLCl) with copper(II) perchlorate led to mononuclear [CuLCl]ClO4 complex (1). The same reaction with excess of sodium azide gives di