25375-38-6

Basic information

• Product Name: 3-hydroxy-5-androsten-17-one
• Synonyms: 3-hydroxy-5-androsten-17-one
• CAS NO: 25375-38-6
• Molecular Weight: 288.43
• Mol File: 25375-38-6.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 3-hydroxy-5-androsten-17-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3-hydroxy-5-androsten-17-one(25375-38-6)
• EPA Substance Registry System: 3-hydroxy-5-androsten-17-one(25375-38-6)

Safety Data

• Hazardous Substances Data: 25375-38-6(Hazardous Substances Data)

Upstream product

• 1093-91-0 (3S,8R,9S,10R,13S,16R)-16-Bromo-3-hydroxy-10,13-dimethyl-1,2,3,4,7,8,9,10,11,12,13,14,15,16-tetradecahydro-cyclopenta[a]phenanthren-17-one 
• 14425-92-4 6β-methoxy-3α,5α-cyclo-14β-androstan-17-one 
• 53-41-8 cis-androsterone 
• 853-23-6 3β-acetoxy-5-androsten-17-one 

Downstream Products

• 510-64-5 19-hydroxy-4-androstene-3,17-dione 
• 734-32-7 estra-4-ene-3,17-dione 
• 63-05-8 Androstenedione 
• 1093-91-0 3β-Hydroxy-16α-brom-androst-5-en-17-on 
• 853-23-6 3β-acetoxy-5-androsten-17-one 
• 63015-10-1 3β-Hydroxy-17-hydrazono-androsten-(5) 
• 521-17-5 androst-5-ene-3β,17β-diol 
• 628-13-7 pyridine hydrochloride 
• 62017-97-4 3-[2-((3aS,4R,5S,7aS)-5-Isopropenyl-7a-methyl-1-oxo-octahydro-inden-4-yl)-ethyl]-phthalic acid dimethyl ester 
• 133522-45-9 14β-androst-5-ene-3β,17α-diyl 3-acetate 17-p-toluenesulfonate 
• 566-19-8 3β-hydroxyandrost-5-ene-7,17-dione 
• 2243-06-3 androst-4-ene-3,6,17-trione 
• 63-05-8 (8R,9S,10R,13S)-10,13-dimethyl-7,8,9,10,11,12,13,14,15,16-decahydro-1H-cyclopenta[a]phenanthrene-3,17(2H,6H)-dione 
• 571-36-8 3,17-Dioxo-androsten-5 

Relevant articles and documents

General, Auxiliary-Enabled Photoinduced Pd-Catalyzed Remote Desaturation of Aliphatic Alcohols

A general, efficient, and site-selective visible light-induced Pd-catalyzed remote desaturation of aliphatic alcohols into valuable allylic, homoallylic, and bis-homoallylic alcohols has been developed. This transformation operates via a hybrid Pd-radical mechanism, which synergistically combines the favorable features of radical approaches, such as a facile remote C-H HAT step, with that of transition-metal-catalyzed chemistry (selective β-hydrogen elimination step). This allows achieving superior degrees of regioselectivity and yields in the desaturation of alcohols compared to those obtained by the state-of-the-art desaturation methods. The HAT at unactivated C(sp3)-H sites is enabled by the easily installable/removable Si-auxiliaries. Formation of the key hybrid alkyl Pd-radical intermediates is efficiently induced by visible light from alkyl iodides and Pd(0) complexes. Notably, this method requires no exogenous photosensitizers or external oxidants.

EPIMERIC 17-HYDROXY DERIVATIVES OF 14β-ANDROST-5-EN-3β-YL ACETATE

A new, six-step synthesis of 3β-hydroxy-14β-androst-5-en-17-one (IX) starting from 3β-hydroxyandrost-5-en-17-one has been elaborated.Reduction of acetate X with sodium borohydride afforded 17α-hydroxy-14β-androst-5-en-3β-yl acetate (XI).The corresponding 17β-derivative XIV was obtained by epimerization of 17α-O-tosyl derivative XIII with sodium nitrite in hexamethylphosphoramide.The 13C and 1H NMR spectra of 14β-androstane derivatives are discussed.