25412-56-0

Basic information

• Product Name: 1,2-Propanedione, 1-(2-methylphenyl)-
• CAS NO: 25412-56-0
• Molecular Formula: C10H10O2
• Molecular Weight: 162.188
• Mol File: 25412-56-0.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 1,2-Propanedione, 1-(2-methylphenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2-Propanedione, 1-(2-methylphenyl)-(25412-56-0)
• EPA Substance Registry System: 1,2-Propanedione, 1-(2-methylphenyl)-(25412-56-0)

Safety Data

• Hazardous Substances Data: 25412-56-0(Hazardous Substances Data)

Upstream product

• 1451-84-9 2-Bromo-1-o-tolyl-propan-1-one 
• 79-20-9 acetic acid methyl ester 
• 201230-82-2 carbon monoxide 
• 6699-93-0 (2-methylphenyl)lithium 
• 14918-24-2 β-methyl-3-methylstyrene 
• 933-88-0 ortho-toluoyl chloride 
• 2040-14-4 2-methylpropiophenone 
• 51052-00-7 1-(2-methylphenyl)acetone 
• 1346260-43-2 (E)-2-(methoxyimino)-1-o-tolylpropan-1-one 
• 75205-42-4 1-(o-methylphenyl)-1-cyanoacetone 
• 615-37-2 ortho-methylphenyl iodide 
• 119072-55-8 tert-butylisonitrile 
• 75-24-1 trimethylaluminum 
• 95-46-5 2-methylphenyl bromide 

Downstream Products

• 82102-48-5 3-bromo-1-o-methylphenylpropane-1,2-dione 

Relevant articles and documents

Palladium-Catalyzed Synthesis of 1,2-Diketones from Aryl Halides and Organoaluminum Reagents Using tert-Butyl Isocyanide as the CO Source

In this work, an interesting and practical procedure for the synthesis of 1,2-diketones from aryl halides and organoaluminum reagents has been developed. Employing tert-butyl isocyanide as the CO source and palladium as the catalyst, the desired 1,2-diketones were isolated in good to excellent yields with good functional group tolerance. Concerning the reaction partners, besides aryl halides, both alkyl- A nd arylaluminum reagents were all suitable substrates here.

THIAZOLE DERIVATIVES

Compounds of formula I are provided as well as pharmaceutically acceptable salts and esters thereof, wherein R1 to R5, n, m and A have the significance disclosed in the specification, and can be used for the treatment or prevention of arthritis, cardiovascular diseases, diabetes, renal failure, eating disorders and obesity.

Direct, Low Temperature, in Situ Nucleophilic Aroylation with Aroyllithium Reagents

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